缓激肽B1(BDKRB1)与宫颈癌的发生与发展  

BDKRB1 and cervical carcinoma occurrence and development

作　　者：范怡冰[1] 何莲芝[1] 

机构地区：[1]皖南医学院弋矶山医院妇产科,芜湖241001

出　　处：《中国优生与遗传杂志》2009年第12期24-25,3,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过检测缓激肽受体B1(bradykinin receptor B1,BDKRB1)在宫颈鳞状上皮病变组织中的表达,探讨其在宫颈癌发生、发展中的作用。方法采用RT-PCR方法检测10例宫颈炎、10例宫颈上皮内瘤变(cervical intraepithe-lial neoplasia,CIN)Ⅰ级、10例CINⅡ～Ⅲ级及30例宫颈鳞状上皮细胞癌(cervical squamous cell carcinoma,CSCC)组织中BDKRB1mRNA表达。结果BDKRB1表达随宫颈上皮病变级别的升高而升高;在CSCC组织中的表达与年龄、临床分期、浸润深度、脉管浸润、淋巴结转移、病理分级等临床病理参数相关;COX回归分析显示年龄、淋巴结转移伴脉管浸润、BDKRB1表达均为影响CSCC患者预后的独立因素。结沦BDKRB1在CSCC的发生、发展过程中起重要作用并与CSCC病人的不良预后相关,有望成为宫颈癌基因治疗的新靶点。Objective： By detecting bradykinin receptor B1 （BDKRB1） expression in cervical squamous intraepithelial lesions , to investigate its role in cervical cancer occurrence and development. Methods ： By means of RT - PCR , we hayed evaluated BDKRB1 expression at mRNA levels in 10 cases cervicitis , 10 cervical intraepithelial neoplasia （CIN） Ⅰ , 10 CIN Ⅱ - Ⅲ and 30 cervical squamous cell carcinoma （CSCC） tissues. Results： BDKRB1 expression gradually increased with cervical intraepithelial lesions grade rising , and have correlation with clinical pathological parameters such as age, clinical stage, depth of invasion, vein Invasion, lymph node metastasis, tumor grade, and so on. Conclusion： BDKRB1 may play an important role in the carcinogenesis and development of CSCC and has correlation with poor prognosis, which is expected to become a new target for gene therapy of cervical cancer.

关 键 词：缓激肽 宫颈上皮内瘤变 宫颈鳞状上皮细胞癌 

分 类 号：R737.33[医药卫生—肿瘤]