220例稽留流产者绒毛组织细胞遗传学分析  

Chromosome karyotyping of 220 cases of early spontaneous abortion

作　　者：古艳[1,2] 谢建生[2] 罗福薇[2] 耿茜[2] 张华坤[2] 沈辉宁[3] 赵坤[3] 刘庆芝[3] 

机构地区：[1]广州医学院 [2]深圳市妇幼保健院产前诊断中心,518048 [3]深圳市妇幼保健院妇科

出　　处：《中国优生与遗传杂志》2009年第12期38-39,19,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过绒毛细胞遗传学分析了解稽留流产患者的病因。方法无菌条件下取220例稽留流产患者胚胎绒毛,采用细胞培养法制备染色体进行G显带分析。结果220例稽留流产患者绒毛细胞培养成功212例(96.36%),收获染色体207例,成功率97.64%(207/212),检出染色体异常115例(55.56%)。异常核型中三体72例(62.61%),性染色体单体16例(13.91%),多倍体14例(12.17%),嵌合体10例(8.70%),结构异常3例(2.61%)。结论胚胎染色体数目异常是稽留流产患者的重要病因,进行绒毛细胞遗传学分析具有重要临床意义。Objective ： To investigate cause of missed abortion. Methods ： Choronic villi from 220 cases of missed abortion were sampled. Tissue culture and karyotype analysis was performed on these samples. Results： The successful cell culture rate was 96. 36% （212/220）. There were 207 （97.64%） cases succeeded in karyotype analysis and 115 cases （55.56 % ） with chromo- some abnormality among 207 cases. Abnormal karyotypes included 72 cases of trisomy, 16 cases of monosomy X, 14 cases of polyploid, 10 cases of chimera and 3 structural abnormity. Conclusion： Chromosome abnormalities was the most important reason in missed abortion, and karyotype analysis of chorionic villus has important clinical significance.

关 键 词：稽留流产 绒毛细胞 染色体分析 

分 类 号：R714.21[医药卫生—妇产科学]