介入治疗对原发性肝癌凝血及纤溶功能影响的临床研究  

THE EFFECT OF BLOOD COAGULATION AND FIBRINOLYTIC FUNCTION THEINTERVENTIONAL THERAPY IN PRIMARY HEPATOCELLULAR CARCINOMA

作　　者：孟晓明[1] 孙亚臣[1] 

机构地区：[1]北华大学附属医院,吉林132011

出　　处：《现代预防医学》2009年第24期4688-4689,共2页Modern Preventive Medicine

摘　　要：[目的]探讨原发性肝癌介入治疗前后凝血及纤溶功能的变化。[方法]选取2007年1月～2009年1月来本院就诊并进行介入治疗的92例原发性肝癌患者作为观察组,正常对照组60例,对比分析两组各项指标。采用ELISA法检测P-选择素、尿激酶型纤溶酶原激活物(uPA)、血管性血友病因子(vWF),采用发色底物法检测纤溶酶原激活物抑制物(PAI),采用光散射比浊法检测凝血酶时间(TT)、活化的部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、凝血因子Ⅶ(FⅦ)、Ⅷ(FⅧ)、Ⅹ(FⅩ)及纤维蛋白原含量(Fg)。[结果]观察组介入治疗后,与治疗前相比,PT、APTT、Ps、VWF和uPA都低于治疗前(P﹤0.05);FⅦ、FⅧ高于治疗前(P﹤0.05)。与对照组相比,PT、APTT、TT、Ps、VWF和uPA都高于对照组(P﹤0.05);Fg、FⅦ、FⅧ和FⅩ都低于对照组(P﹤0.05)。[结论]介入治疗能够减轻原发性肝癌患者的凝血和纤溶功能亢进,但不能恢复正常。[Objective] To explore the changes of blood coagulation and fibrinolytic function before and after intervention-al therapy of primary hepatocellular carcinoma.[Methods] 92 patients with primary hepatocellular carcinoma were observation group in our hospital from 2007 to 2009,while 60 patients were recruited as control group.Prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinoger（Fg）,coagulate factor Ⅶ（FⅦ）,factor Ⅷ（FⅧ）and factor Ⅹ（FⅩ）in group before interventional therapy of primary hepatocellular carcinoma and after that.[Results] PT,APTT,Ps,VWF and uPA in observation group were higher before interventional therapy than those after interventional therapy（P﹤0.05）,while Fg,FⅦ,FⅧ and FⅩ was lower（P﹤0.05）.Compared with control group,PT,APTT,TT,Ps and VWF and uPA were higher in observation group（P﹤0.05）,while Fg,FⅦ,FⅧ and FⅩ were lower in observation group（P﹤ 0.05）.[Conclusion] Interventional therapy can improve blood coagulation and fibrinolytic function of patients with primary hepatocellular carcinoma.But blood coagulation and fibrinolytic function of patients can＇t turn to the normal.

关 键 词：原发性肝癌 凝血 纤溶 介入 

分 类 号：R735.7[医药卫生—肿瘤]