莪术油干预治疗DMBA诱导大鼠乳腺癌癌前病变的组织病理学研究  

Study of Curzerene Curing the Animal Model Of Breast Precancer Rats induced by DMBA

作　　者：宋爱莉[1] 殷玉琨[1] 李静蔚[1] 刘晓菲[1] 胡倩[1] 

机构地区：[1]山东中医药大学附属医院,山东济南250011

出　　处：《中华中医药学刊》2009年第12期2496-2499,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30472219);教育部博士点基金资助项目(20040441025)

摘　　要：目的:通过观察莪术油对乳腺癌癌前病变造模大鼠乳腺组织病理形态的影响,探讨莪术油对乳腺癌癌前病变的治疗作用。方法:将256只SD大鼠随机分为空白对照组、疾病模型组、三苯氧胺组、康莱特组及莪术油大、中、小剂量组。采用DMBA诱导乳腺癌癌前病变造模,第2天开始进行干预治疗,分别于第8周末、第10周末、第12周末、第14周末进行组织病理学观察、分析。结果:疾病模型组与空白对照组比较,大鼠死亡率、癌前病变发生率、乳腺癌发生率增高(P<0.05)。莪术油中、小剂量组大鼠死亡率、癌前病变发生率、乳腺癌发生率降低,与病模组及康莱特组比较差异显著(P<0.05),与三苯氧胺组比较无显著差异(P>0.05)。结论:莪术油可降低乳腺癌癌前病变造模大鼠的癌变发生率及死亡率,可在癌前病变阶段预防、逆转、阻断乳腺癌的发生发展。Objective： To research the effect of treating breast precancer with Curzerene by observed in Pathological Changes. Methods： 256 SD rats were randomly divided into seven groups：the blank control group, the breast precancer model group, the comparative group of kanglaite, the comparative group of tamoxffen, large middle and small remedial groups of Curzerene, Animal model of rat breast precancer was induced with DMBA. Interpose treatment was performed the second day, effect and analysis of pathology the 8th 10th 12th and 14th week. Results： Compared with the blank control group, the rate of death of the breast precancer model group increased （ P 〈 0.05）, the probability of cancer, pre-cancer and death of the middle and small remedial groups of Curzerene decreased, Compared with the breast precancer model group had significant difference（ P 〈0.05）, Compared with group of tamoxifen hadn＇t significant difference（ P 〉 0. 05）. Conclusion： Curzerene could cure and prevent breast precancer.

关 键 词：乳腺癌癌前病变 病理 动物模型 莪术油 实验研究 

分 类 号：R737.9[医药卫生—肿瘤]