宁夏回族人群CYP2D6*10等位基因及基因型分布频率  

The Allele and Genotype Frequences of CYP2D6*10 in Ningxia Hui Population

作　　者：李宗吉[1] 王健[2] 王惠成[2] 葛立军[2] 

机构地区：[1]宁夏医科大学医学科学技术研究中心,银川750004 [2]宁夏回族自治区人民医院,银川750021

出　　处：《宁夏医科大学学报》2009年第6期720-722,共3页Journal of Ningxia Medical University

基　　金：宁夏自然科学基金资助(NZ07109);宁夏卫生厅重点科研课题(W200707)

摘　　要：目的了解宁夏回族人群CYP2D6*10等位基因及基因型分布频率,为临床使用CYP2D6底物药物提供依据。方法采用等位基因特异扩增(ASA-PCR)技术,分析了180例回族体检者的CYP2D6基因型。结果CYP2D6*10基因点突变结果中野生型纯合子频率为32.3%,杂合子频率为38.3%,突变型纯合子频率为29.4%,突变型等位基因频率为48.6%。结论宁夏回族人群CYP2D6*10突变基因频率与国内外其他民族有一定差异,在临床应用经CYP2D6代谢的药物时应考虑个体间的代谢速率差异,确保用药安全有效。Objective To investigate the allele and genotype frequences of CYP2D6＊10 in Ningxia Hui population.Methods 180 Ningxia Hui blood samples were collected.The ASA-PCR was performed and the PCR products were genotyped.Results The mutant allele frequences were 48.6%.Conclusion CYP2D6＊10 allele frequences between Ningxia hui ethnicity and other populations was significantly different.

关 键 词：CYP2D6＊10 基因 多态性 回族 

分 类 号：R394[医药卫生—医学遗传学]