常用脊髓损伤模型与骨髓间充质干细胞移植治疗脊髓损伤  

Application of common spinal injury models and bone marrow mesenchymal stem cells transplantation in the treatment of spinal cord injury

作　　者：李东君[1] 贾全章 

机构地区：[1]延边大学医学部,吉林省延吉市133000 [2]解放军第二○八医院脊柱外科,吉林省长春市130062

出　　处：《中国组织工程研究与临床康复》2009年第45期8979-8982,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：脊髓损伤的病理生理机制非常复杂,建立适宜的脊髓损伤模型,对模型进行骨髓间充质干细胞移植治疗,并分析其治疗脊髓损伤的机制,是进行临床脊髓损伤治疗的前提。目前常用的脊髓损伤模型包括挫伤型模型、牵张损伤模型、压迫损伤模型、切割或吸除型模型、缺血损伤模型等。常用的骨髓间充质干细胞移植方法有细胞悬液立体定位注射法、腰穿细胞悬液注射法、静脉内细胞悬液输入法等。骨髓间充质干细胞治疗脊髓损伤的机制可能有以下几方面:①骨髓间充质干细胞能向损伤处迁移,并向神经细胞表型分化。②发挥桥梁介导作用。③骨髓间充质干细胞移植后能够抑制神经细胞的凋亡。大量动物实验结果证明,骨髓间充质干细胞移植治疗脊髓损伤的临床应用前景是广阔的。The pathophysiological mechanism of spinal cord injury is very complex. In order to find out the clinical treatment for spinal cord injury, the suitable design of a spinal cord injury experimental model is critically important to explore the mechanism in treatment the spinal cord injury, by which the transplantation of bone marrow mesenchymal stem cells could be conducted. Nowadays, several methods have already existed on the design of spinal cord injury experimental model, including contused model, tension model, compression model, cutting model or resorption model, and ischemia model, and the way of bone marrow mesenchymal stem cells transplantation, including cell suspension stereotaxis injection, lumbar puncture cell suspension injection, and intravenous cell suspension injection. The possible mechanisms of bone marrow mesenchymal stem cells in treatment of spinal cord injury were as follows： ① bone marrow mesenchymal stem cells could move to the damage department and differentiate into neural cell phenotype; ② bone marrow mesenchymal stem cells could play the role of bridge-mediation; ③bone marrow mesenchymal stern cells could inhibit the apoptosis of the nerve cells after transplantation. Animal experiments proved that there are broad prospects of clinical application of bone marrow mesenchymal stem cells for the treatment of spinal cord injury.

关 键 词：骨髓间充质干细胞 移植 脊髓损伤 

分 类 号：R394.2[医药卫生—医学遗传学]