Stathmin在脑胶质瘤血管内皮细胞中的表达及意义  

Expression and significance of Stathmin in human glioma vascular endothelial cells

作　　者：刘晓东[1] 慕璐岩[2] 刘晓谦[2] 

机构地区：[1]吉林省通化市人民医院神经外科,134000 [2]哈尔滨医科大学附属第四临床医学院神经外科,哈尔滨150001

出　　处：《中华神经医学杂志》2009年第12期1213-1216,共4页Chinese Journal of Neuromedicine

摘　　要：目的观察Stathmin及CD105在脑胶质瘤血管内皮细胞中的表达，探讨其在脑胶质瘤血管形成中的作用。方法用SP免疫组化法检测10例正常脑组织和78例脑胶质瘤血管内皮细胞中Stathmin和CD105蛋白表达，并通过检测肿瘤微血管密度（MVD）分析肿瘤血管形成。结果正常脑组织血管内皮细胞中Stathmin和CD105均无表达．脑胶质瘤血管内皮细胞中二者均呈高表达；随着胶质瘤病理级别的增高，Stathmin和CD105表达上调，MVD值增高，Stathmin—MVD和CD105-MVD与脑胶质瘤病理分级均成正相关（r=0．912，P〈0．05；r=0．936，P〈0．05）；且Stathmin—MVD和CD105-MVD之间也存在正相关（r=0．996，P〈0．05）。结论Stathmin与CD105在脑胶质瘤血管内皮细胞中均呈高表达，在肿瘤微血管形成过程起重要作用。Objective To observe the expressions of stathmin and CD105 in human glioma vascular endothelial cells and explore their significant roles in glioma angiogenesis. Methods The protein expressions of stathmin and CD105 in the vascular endothelial cells was examined by SP immunohistochemical staining in 10 normal cerebral tissue samples and 78 cases of glioma. The microvessel density （MVD） was measured to analyze the tumor angiogenesis. Results No expression of statnmin and CD 105 was found in the normal human brain tissue; while high expression level of both stathmin and CD105 was showed in the vascular endothelial cells of glioma. The expression level of stathmin and CD105 and the value of MVD increased following the rise of the pathological grades of glioma; significant linear correlation was showed between the values of stathmin-MVD and CD105-MVD and the pathological grades of the glioma （r=0.912, P〈0.05; r=0.936, P〈0.05）; stathmin-MVD and CD105-MVD were also positively correlative （r=0.996, P〈0.05）. Conclusion The Stathmin and CD105 is highly expressed in the vascular endothelial cells of human glioma, suggesting its important role in the tumor angiogenesis.

关 键 词：STATHMIN CD105 血管内皮细胞 神经胶质瘤 

分 类 号：R686[医药卫生—骨科学]