supported by grants from Guangdong Basic and Applied Basic Research Foundation(2023A1515010477);the National Natural Science Foundation of China(32000690);the Key-Area Research and Development Program of Guangdong Province,China(2019B030335001);the Key Medical and Health Projects of Panyu District Science and Technology Plan,Guangzhou,China(2023-Z04-103).
Main text Amyotrophic lateral sclerosis(ALS)is a neurodegenera-tive disease characterized by the selective loss of motor neurons(MNs),resulting in progressive disability and mortality with a rapid course.Current appro...