supported by grants from Guangdong Basic and Applied Basic Research Foundation(2023A1515010477);the National Natural Science Foundation of China(32000690);the Key-Area Research and Development Program of Guangdong Province,China(2019B030335001);the Key Medical and Health Projects of Panyu District Science and Technology Plan,Guangzhou,China(2023-Z04-103).
Main text Amyotrophic lateral sclerosis(ALS)is a neurodegenera-tive disease characterized by the selective loss of motor neurons(MNs),resulting in progressive disability and mortality with a rapid course.Current appro...
A.F.is supported by the Deutsche Forschungsgemeinschaft(DFG;grant#521487152).We apologize to all our colleagues whose work could not be cited here due to space limitations.
In a recent study published in Science,Baughn et al.revealed that TDP-43 acts as a steric block in STMN2 pre-mRNA processing preventing inclusion of a deleterious cryptic exon,and present strategies for substituting t...