supported by the National Institutes of Health R01(grant 5R01AT010593-03);the National Science Foundation TRTech-PGR(grant 2312181).
The diversity of plant natural products presents a rich resource for accelerating drug discovery and addressing pressing human health issues.However,the challenges in accessing and cultivating source species,as well a...
support from the National Natural Science Foundation of China(Nos.21901215,21672030);the Fundamental Research Funds for the Central Universities(No.2682021CG020).
Taxol is one of the most famous diterpenoid natural products used in clinical cancer therapy.Taxol and its analogues are popular synthetic targets and have attracted worldwide attention over the past decades.Tremendou...
This work was supported by National Natural Science Foundation of China(31570675);a Grant from the National Key Research and Development Program of China(2017YFD060070605);a Grant for National non-profit Research Institutions of Chinese Academy of Forestry(CAFYBB2018SY009).
Taxol(Paclitaxel),an important anticancer drug,is derived at very low yields from Taxus(yew)species that grow very slowly.In the present study,thirteen genes that encode enzymes involved in Taxol biosynthesis in Taxus...
supported by the National Key Research and Development Program of China(grant Nos.2018YFA0901900 and 2020YFA0908003);the Drug Innovation Major Project(grant No.2018ZX09711001-006-001,China);the National Natural Science Foundation of China(grant No.81573325);the CAMS Innovation Fund for Medical Sciences(CIFMS,(grant No.2017-I2M-2-004,2019-I2M-1-005,China);PUMC Disciplinary Development of Synthetic Biology(201920100801,China)。
10-DeacetylbaccatinⅢ(10-DAB)C10 acetylation is an indispensable procedure for Taxol semi-synthesis,which often requires harsh conditions.10-DeacetylbaccatinⅢ-10-β-O-acetyltransferase(DBAT)catalyzes the acetylation ...