Plants against cancer:towards green Taxol production through pathway discovery and metabolic engineering  

作　　者：Philipp Zerbe 

机构地区：[1]Department of Plant Biology,University of California Davis,Davis,CA 95616,USA

出　　处：《aBIOTECH》2024年第3期394-402,共9页生物技术通报（英文版）

基　　金：supported by the National Institutes of Health R01(grant 5R01AT010593-03);the National Science Foundation TRTech-PGR(grant 2312181).

摘　　要：The diversity of plant natural products presents a rich resource for accelerating drug discovery and addressing pressing human health issues.However,the challenges in accessing and cultivating source species,as well as metabolite structural complexity,and general low abundance present considerable hurdles in developing plant-derived therapeutics.Advances in high-throughput sequencing,genome assembly,gene synthesis,analytical technologies,and synthetic biology approaches,now enable us to efficiently identify and engineer enzymes and metabolic pathways for producing natural and new-to-nature therapeutics and drug candidates.This review highlights challenges and progress in plant natural product discovery and engineering by example of recent breakthroughs in identifying the missing enzymes involved in the biosynthesis of the anti-cancer agent Taxol^(®).These enzyme resources offer new avenues for the bio-manufacture and semi-synthesis of an old blockbuster drug.

关 键 词：TAXOL Plant natural products Synthetic biology Pathway discovery Metabolic engineering 

分 类 号：R73[医药卫生—肿瘤] Q94[医药卫生—临床医学]