Diverse strategic approaches en route to Taxol total synthesis  

作　　者：Zexian Li Jianfeng Zheng Wei-Dong Z.Li 

机构地区：[1]Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs,School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China

出　　处：《Chinese Chemical Letters》2022年第12期4957-4968,共12页中国化学快报（英文版）

基　　金：support from the National Natural Science Foundation of China(Nos.21901215,21672030);the Fundamental Research Funds for the Central Universities(No.2682021CG020).

摘　　要：Taxol is one of the most famous diterpenoid natural products used in clinical cancer therapy.Taxol and its analogues are popular synthetic targets and have attracted worldwide attention over the past decades.Tremendous research efforts have already been made and ten groups have achieved the total synthesis of Taxol since 1994.This mini-review summarized the recent highlights of divergent strategic approaches towards the chemical synthesis of Taxol's carbocyclic framework bearing a bridged eight-membered ring.

关 键 词：TAXOL Total synthesis Biomimetic synthesis Linear strategy Convergent strategy 

分 类 号：TQ464.2[化学工程—制药化工]