基质金属蛋白酶血清含量与膀胱移行细胞癌浸润转移的关系  

Correlations of matrix metalloproteinase content with invasion and metastasis of the transitional cell carcinoma of bladder

作　　者：朱峰[1] 张艳[2] 张会清[1] 张英杰[1] 

机构地区：[1]新乡医学院第一附属医院泌尿外科,河南卫辉453100 [2]新乡医学院科技处机能学实验室,河南新乡453001

出　　处：《现代泌尿外科杂志》2009年第6期445-446,共2页Journal of Modern Urology

摘　　要：目的探讨基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-9(MMP-9)的血清含量与膀胱移行细胞癌侵袭转移的关系。方法采用酶联免疫吸附试验(ELISA)对46例膀胱移行细胞癌患者血清中的MMP-2及MMP-9进行测定,并与18例正常血清进行对照分析。结果膀胱移行细胞癌患者同正常对照组比较,血清中MMP-2和MMP-9含量均显著增高(P<0.000),血清中MMP-2和MMP-9含量随着临床分期的升高均有显著性增高(P<0.0000),膀胱癌组织学Ⅱ、Ⅲ级患者血清中MMP-2和MMP-9含量明显高于I级(P<0.0000),但两者间比较无显著性差异(P>0.05)。结论MMPs与膀胱移行细胞癌的发生、发展及侵袭转移密切相关,MMPs血清学测定可作为判断膀胱肿瘤预后的指标之一。Objective To investgate the correlations of serum matrix metalloptoteinase-2, -9 （MMP-2, MMP-9） contents in the transitional cell carcinoma of bladder （TCCB） with tumor invasion and metastasis. Methods Serum MMP-2 and MMP- 9 contents were detected in 46 patients with transitional cell carcinoma of bladder and 18 healthy controls by enzyme-linked immunosorbent assay （ELISA）. Results Serum MMP-2 and MMP-9 contents were significantly elevated in cancer samples compared with normol control group （P〈0.000）, serum MMP-2 and MMP-9 contents had significant difference along with clinical stages elevation （P〈0.000）. MMP-2 and MMP-9 contents in stage Ⅱ and stage Ⅲ were obviously higher than in stage Ⅰ（P〈0.000）, but there was no significant relationship between stage Ⅲ and stage Ⅱ（P〉0.05）. Conclusion MMPs was closely related with the occurrence, development and invasion and metastasis of urinary bladder transitional cell cancer. Sero- logical determination of MMPs could be used as one of the prognostic indicators in the transitional cell carcinoma of bladder.

关 键 词：基质金属蛋白酶 明胶酶-A/B 胱移行细胞癌 侵袭转移 

分 类 号：R737.14[医药卫生—肿瘤]