白术对大鼠脑出血后小肠粘膜形态学变化的影响  

The Morphological Alterations of Intestinal Mucosa in Rats with Cerebral Hemorrhage and the Effects of Largehead Atractylodes Rhizome on these Alterations

作　　者：王建林[1] 张苏明[1] 杨志秀[2] 张晓敏[2] 范云虎[2] 张扬[2] 王静梅[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经科,武汉430030 [2]云南省第二人民医院神经内科,昆明650021

出　　处：《神经损伤与功能重建》2009年第6期399-401,407,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:评价白术对脑出血大鼠小肠粘膜形态学的影响。方法:56只SD大鼠随机分为模型组24只、治疗组24只及对照组8只,对照组不予任何处理,模型组和治疗组制备脑出血大鼠模型后分别采用灌胃法每天灌注生理盐水和白术液(0.2 g/mL)。检测并分析对照组及脑出血后第1、7、14天模型组、治疗组(每时间点各取8只)小肠粘膜的形态学参数。结果:与对照组比较,模型组脑出血后绒毛面积降低最快最明显,绒毛高度及粘膜厚度逐渐降低,肠腺密度和深度先降低后增高。与模型组比较,治疗组于脑出血后第1天小肠绒毛高度、粘膜厚度明显降低(P<0.01),绒毛面积略降,肠腺密度及深度略增;第7天小肠绒毛高度、绒毛面积及粘膜厚度略降,肠腺密度及深度明显增大(P<0.01);第14天小肠绒毛高度、绒毛面积及粘膜厚度明显增加(P<0.01),肠腺密度及深度略降。结论:脑出血可以引起小肠粘膜萎缩;白术可改变脑出血大鼠的小肠粘膜形态,从而促进大鼠肠道功能的恢复。Objective：To observe the morphological alterations of small intestinal mucosa in rats with cerebral hemorrhage and evaluate the effects of largehead atractylodes rhizome on these alterations.Methods：56 SD rats were randomly divided into control（n=8）,hemorrhage（n=24） and therapeutic groups（n=24）.The morphological alterations of jejunal mucosa of the rats in the three groups were detected and analyzed at days 1,7 and 14 after cerebral hemorrhage.Results：Of the three groups,the small intestinal villus area of the rats in the hemorrhage group was decreased quickest and most severely,and the small intestinal villus height and mucosal thickness were decreased gradually,but the density and depth of small intestinal gland were decreased at first and increased subsequently.In contrast,the small intestinal villus area of the rats in the therapeutic group was decreased slightly,and the small intestinal villus height and mucosal thickness were decreased significantly（P0.01）,and the density and depth of the small intestinal gland were increased slightly at day 1 after cerebral hemorrhage.At day 7,the small intestinal villus area,villus height and mucosal thickness were decreased slightly,but the density and depth of small intestinal gland were increased significantly.At day 14,the small intestinal villus area,villus height and mucosal thickness were increased significantly（P0.01）,but the density and depth of small intestinal gland were decreased slightly.Conclusion：The cerebral hemorrhage can cause atrophy of the small intestinal mucosa of rats and largehead atractylodes rhizome can exert protective effect on the small intestinal mucosa.

关 键 词：白术 脑出血 大鼠 肠粘膜结构 模型组 小肠绒毛高度 膜厚度 形态学参数 肠腺 对照组 

分 类 号：R741[医药卫生—神经病学与精神病学] R743.34[医药卫生—临床医学]