癫发作后血清超敏C反应蛋白含量的变化  

Changes of the Concentration of Blood Serum High-sensitivity C-reactive Protein after Epileptic Seizure

作　　者：李洪亮[1] 王守勇[1] 蒋敏[2] 徐建洋[1] 杜俊秋[1] 张亚东[1] 

机构地区：[1]淮安市第三人民医院,江苏淮安223001 [2]淮安市第一人民医院,江苏淮安223001

出　　处：《神经损伤与功能重建》2009年第6期412-413,共2页Neural Injury and Functional Reconstruction

摘　　要：目的：探讨癫发作后血清超敏C反应蛋白（hsCRP）含量的变化。方法：选取癫患者75例（癫组）,据入院时距末次癫发作的不同时间（24 h内2、4~48 h4、8~72 h）采血,测定并比较癫患者在各时间点的血清hsCRP含量;另取门诊健康体检者19例（对照组）采血,比较发作≤1次/周的癫患者发作后24 h内和对照组的血清hsCRP含量。结果：癫患者发作后血清hsCRP含量于发作后24 h内明显增高,之后随时间的推移逐渐下降;发作≤1次/周的癫患者发作后24 h内血清hsCRP含量较对照组明显升高（P0.01）。结论：癫发作可引起脑神经元损伤,并伴有血清hsCRP含量的升高。Objective：To explore changes of the concentration of high-sensitivity C-reactive protein（hsCRP） in serum after epileptic seizure.Methods： Blood samples of 75 patients with epilepsy（epilepsy group） have been collected at 0～24 h,24～48 h or 48～72 h after the last seizure and the concentration of blood serum hsCRP was analyzed at different time points.Ninteen controls from the outpatient service were treated as controls.The concentration of blood serum hsCRP at 0～24 h after the last seizure in the patients who had only once seizure within a week was compared with that from the control group.Results： The concentration of blood serum hsCRP collected at 0～24 h after epileptic seizure was increased significantly and then decreased gradually.The concentration of blood serum hsCRP 0～24 h after the last seizure from the patients was significantly increased（P0.01） when compared with that in the controls.Conclusion： An epileptic seizure may damage neurons.Blood serum hsCRP might be considered as a symbol to evaluate the damage.

关 键 词：癫发作 神经元损伤 超敏C反应蛋白 血清 健康体检 免疫损伤 标志物 对照组 患者 蛋白含量 

分 类 号：R741[医药卫生—神经病学与精神病学] R742.1[医药卫生—临床医学]