S100和CD83阳性树突状细胞与大肠肿瘤微环境的关系  

Inf iltration of S100-and cluster of differentiation 83-positive dendritic cells in colorectal tumors

作　　者：詹俊[1] 孙小娟 李楚强[1] 于钟[1] 

机构地区：[1]中山大学附属第二医院消化内科,广东省广州市510120 [2]广州市南沙中心医院消化内科,广东省广州市511457

出　　处：《世界华人消化杂志》2009年第29期3061-3065,共5页World Chinese Journal of Digestology

基　　金：广东省自然科学基金资助项目;No.7001610~~

摘　　要：目的:探讨大肠癌与大肠腺瘤组织中树突状细胞(dendriticcells,DCs)浸润,了解局部组织的免疫状态对大肠肿瘤发生的影响.方法:采用免疫组织化学SP法检测25例大肠癌与31例大肠腺瘤患者肿瘤组织、肿瘤旁组织以及远处正常大肠黏膜中S100+DCs及CD83+DCs的浸润.结果:大肠癌组织中浸润的S100+DCs、CD83+DCs细胞数明显少于癌旁组织、正常组织以及大肠腺瘤组织,差异均有统计学意义(S100+DCs细胞数:15.36±1.78vs25.14±2.81,32.55±2.65,33.77±3.06;CD83+DCs细胞数:2.50±0.60vs4.91±0.51,5.68±1.14,5.39±0.68,均P<0.05);大肠腺瘤组织中浸润的S100+DCs细胞数明显多于腺瘤旁组织与正常组织(均P<0.05),而CD83+DCs则无差异.结论:DCs在大肠肿瘤中的浸润情况有助于了解肿瘤的免疫逃逸及大肠肿瘤发生的机制.AIM： To investigate the inf iltration of S100-and cluster of differentiation 83 （CD83）-positive dendritic cells （DCs） in colorectal carcinoma and adenoma and observe the effect of local immunity on the development of colorectal tumors. METHODS： Twenty-five colorectal carcinoma patients and 31 colorectal adenoma patients were included in the study. The infiltration of S100＋ and CD83＋ DCs in tumor, tumor-adjacent and tumor-distant tissues was detected by immunohistochemistry using the streptavidinperoxidase method. RESULTS： The number of S100＋ DCs and CD83＋ DCs were significantly less in colorectal carcinoma than in tumor-adjacent and tumor- distant tissues and colorectal adenoma （S100＋ DCs： 15.36 ± 1.78 vs 25.14 ±2.81, 32.55± 2.65 and 33.77 ± 3.06, respectively; CD83＋ DCs： 2.50 ± 0.60 vs 4.91 ± 0.51, 5.68 ± 1.14 and 5.39±0.68, respectively; all P 〈 0.05）. The number of S100＋ DCs was significantly higher in colorectal adenoma than in tumor-adjacent and tumor-distant tissues （both P 〈 0.05）, while no statistical differences were noted in the number of CD83＋ DCs among colorectal adenoma and tumor-adjacent and tumor-distant tissues. CONCLUSION： Detection of DC infiltration in colorectal tumors is helpful in understanding tu- mor immune evasion and tumor development.

关 键 词：大肠癌 大肠腺瘤 树突状细胞 S100 CD83 

分 类 号：R735.34[医药卫生—肿瘤] R730.51[医药卫生—临床医学]