幽门螺杆菌感染对老年人胃黏膜环氧合酶-2表达的影响及意义  

Effects of Helicobacter pylori infection on cyclooxygenase-2 expression in gastric mucosal epithelium of elderly population

作　　者：王琳[1] 任美书[1] 王鸿博[1] 张蕴[1] 章明放[1] 

机构地区：[1]天津医科大学总医院干部病房,天津市300052

出　　处：《世界华人消化杂志》2009年第30期3140-3143,共4页World Chinese Journal of Digestology

基　　金：天津市卫生局科技基金资助项目;No.07KZ24~~

摘　　要：目的:评估幽门螺杆菌(Hpylori)感染对老年人胃黏膜COX-2表达的影响及意义.方法:取不同阶段的胃黏膜病变共200例,用速尿素酶试验结合组织学Giemsa染色或14C尿素呼气试验检测胃黏膜Hpylori感染状况,应用免疫组织化学检测胃黏膜上皮细胞COX-2的表达.结果:不同组织类型Hpylori检出率以胃癌最高,其次为不典型增生(AH)和肠上皮化生(IM).COX-2在慢性浅表性胃炎(CSG)、IM、AH和胃癌中的表达阳性率分别为8%、24%、46%和64%,呈递增趋势,其阳性率胃癌与非癌组织相比差异均有统计学意义(P<0.01).同一类型Hpylori阳性组COX-2的表达高于Hpylori阴性组,2组比较有显著性差异(P<0.05).结论:COX-2表达上调与Hpylori感染的胃黏膜的癌变有关,可能在癌前病变早期阶段起作用.AIM： To investigate the effects of Helicobacter pylori （H pylori） infection on cyclooxygenase-2 （COX-2） expression in gastric mucosal epithelium. METHODS： A total of 200 patients with gastric mucosal lesions at different stages of carcinogenesis were included in the study. Rapid urease test in combination with Giemsa staining or 14C urea breath test was used to assess H pylori infection in these patients. COX-2 expression in gastric mucosal epithelium was detected by immunohistochemistry （IHC）. RESULTS： The detection rate of H pylori infec-tion was highest in patients with gastric cancer （GCA）, followed by patients with atypical hyperplasia （AH） and intestinal metaplasia （IM）. The positive rates of COX-2 expression in patients with chronic superficial gastritis （CSG）, IM, AH and GCA were 8%, 24%, 46% and 64%, respectively, exhibiting an upward trend. Significant difference was noted in the positive rate of COX-2 expression between GCA and nonGCA patients （P〈0.01）. The positive rate of COX-2 expression was significantly higher in H pylori-positive patients than in H pylori-negative patients （P〈0.05）. CONCLUSION： The upregulation of COX-2 expression is associated with the malignant transformation of H pylori-infected gastric mucosa and may play a role in the development of early premalignant lesions.

关 键 词：幽门螺杆菌 环氧合酶-2 胃黏膜癌变 上皮细胞 

分 类 号：R573[医药卫生—消化系统] R259.753[医药卫生—内科学]