多体素磁共振质子波谱分析在正常成人脑组织发育的研究  

Proton magnetic resonance spectroscopy for evaluating the development of the normal adult brain

作　　者：黄华[1] 冯占辉[2] 吕发金[3] 何选丽[2] 黄敏[2] 晏勇[2] 

机构地区：[1]达州市中心医院神经内科,达州635000 [2]重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室 [3]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《重庆医科大学学报》2009年第11期1531-1533,共3页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(30570636)

摘　　要：目的:应用多体素2D1H-MRS观察正常成人大脑顶叶皮质主要代谢化合物随年龄变化规律。方法:应用场强为1.5T的磁共振成像系统对50例正常人(19～49岁)大脑顶叶皮质进行1H-MRS采集。计算氮-乙酰门冬氨酸(NAA)与肌酸(Cr)的峰下面积比值以及胆碱复合物(Cho)与肌酸(Cr)峰下面积的比值,并分别与年龄进行相关分析。结果:NAA/Cr值与年龄增长无明显相关性。Cho/Cr值随年龄增长呈显著递减。结论:多体素磁共振质子波谱可无创观察不同年龄组正常成人大脑顶叶皮质代谢情况,获得主要代谢产物与年龄的关系,为临床提供参考。Objective：To discover the metabolic change of brain with age in normal adults by using volume-selective, two dimensional ^1H-MRS. Methods： ^1H-MRS was obtained from 50 normal persons aged from 19 to 49 years with the use of PRESS sequence. The areas under the peaks were measured; the ratio of N-acetylaspartate （NAA, choline （Cho） to creatine （Cr）were caculated. The relationship between the decreased ratio of NAA/Cr and Cho/Cr, and age was examined by statistics method. Results ：We found there was no relationship between NAA/Cr and age. The ratio of Cho/Cr decreased with age. Conclusion： MRS can detect the metablolic change of the brain with age in normal people, and show the development of the normal brain noninvasively.

关 键 词：正常成人 脑 多体素磁共振波谱 

分 类 号：R742.8[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]