监测血清TNF-α和IL-6水平在重症急性胰腺炎患者的变化及意义  

Dynamic Changes and Clinical Significance of Serum TNF-α and IL-6 in Severe Acute Pancreatitis

作　　者：柴虎林[1] 王德强[1] 刘铁军[1] 

机构地区：[1]包头医学院第一附属医院普外科,内蒙古包头014010

出　　处：《中国现代医生》2009年第34期4-5,共2页China Modern Doctor

摘　　要：目的探讨TNF-α和IL-6在重症急性胰腺炎(SAP)患者血清中的变化及临床意义。方法应用ELISA法检测32例重症急性胰腺炎及25例对照组血清TNF-α、IL-6的水平变化。结果入院时SAP患者TNF-α水平(48.5±12.1)pg/mL显著高于对照组(13.5±3.8)pg/mL,IL-6水平SAP患者(66.7±19.3)pg/mL较对照组(42.3±14.2)pg/mL无明显升高;SAP患者血清IL-6在入院的第7天升高最明显(180.1±41.4)pg/mL,高于对照组,在入院第14天SAP患者血清TNF-α(29.5±9.5)pg/mL,IL-6(102.8±24.6)pg/mL仍然高于对照组。结论检测血清TNF-α和IL-6的水平变化,对重症急性胰腺炎的早期诊断、病情判断和预后评估具有重要的应用价值。Objective To investigate the changes and clinical significance of serum TNF-α and IL-6 in severe acute pancreatitis （SAP）. Methods The serum levels of TNF-α and IL-6 in 32 cases of SAP and 25 normal controls were determined by EL ISA. Results On admission, the serum TNF-α level of the SAP group（48.5 ± 12.1pg/mL） was significantly higher than that of the control group（13.5 ±3.8pg/mL）,while the serum IL-6 level of the SAP group（66.7 ±19.3pg/mL） showed no significant difference from that of the control group compared with the control group（42.3 ± 14.2pg/mL）. The serum IL-6 level of the SAP group（180.1 ± 41.4pg/mL） was significantly higher than that of the control group on Day 7 after admission;the serum levels of TNF-α and IL-6 in the SAP group （29.5 ±9.5pg/mL） and （102.8±24.6pg/mL） were significantly higher than those of the control group but there was no significant difference between the SAP group and the control group on Day 14 after treatment. Conclusion The determination of the serum levels of TNF-α and IL-6 may be of great value for early diagnosis,judgment of severity and prognosis of severe acute pancreatitis.

关 键 词：重症急性胰腺炎 肿瘤坏死因子-α 白细胞介素-6 

分 类 号：R576[医药卫生—消化系统]