帕金森病患者自主神经功能障碍相关研究  

Correlated study of autonomic dysfunction in patients with Parkinson' s disease

作　　者：焦玲[1] 王立侠[1] 楚兰[1] 

机构地区：[1]贵阳医学院附属医院神经科,贵州贵阳550004

出　　处：《中风与神经疾病杂志》2009年第6期697-700,共4页Journal of Apoplexy and Nervous Diseases

基　　金：贵州省科技支撑计划项目黔科合[SY字(2008)3046]

摘　　要：目的评估交感神经皮肤反应(sympathetic skin response,SSR)和PD自主神经症状量表(the scale for outcomes in PD for autonomic symptoms,SCOPA-AUT)对帕金森病(Parkinson disease,PD)患者自主神经功能损害的诊断价值及自主神经功能障碍影响因素。方法应用SSR、SCOPA-AUT和统一帕金森病评分量表(unified Par-kinson disease rating scale,UPDRS)对50例PD患者进行评估;应用SSR及SCOPA-AUT量表对33例对照组进行评估。结果PD组四肢SSR的潜伏期及波幅与对照组相比差异有显著统计学意义(P<0.01或0.05)。SCOPA-AUT总分(23.54±12.48)、消化系统症状(8.00±3.77)及泌尿系统症状评分(6.28±3.51)均高于对照组,差异有统计学意义(P<0.01)。SCOPA-AUT总分与UPDRS评分、H&Y分级、Schwab和England日常生活得分显著相关,差异有统计学意义(P<0.01或0.05),与病程、年龄无明显的相关性(P(0.05)。结论PD患者自主神经功能障碍随着病情进展而加重,PD患者SCOPA-AUT评分与上、下肢SSR波幅呈负相关,SSR和SCOPA-AUT可作为评价PD患者自主神经功能障碍的客观量化临床指标。Objective To investigate the diagnostic value of sympathetic skin response（SSR） and the scale for outcomes in PD for autonomic symptoms（SCOPA-AUT） in autonomic dysfunction and influencing factors of autonomic dysfunction in patients with parkinson＇s disease（PD）.Methods SSR,SCOPA-AUT and unified Parkinson＇s disease rating scale（UPDRS） were used to evaluate 50 patients with PD.The results were taken from patients with PD and compared with those of 33 control subjects.Results It was significantly different to compare the SSR latency and amplitude of PD patients limbs with those of the normal controls.PD patients had more total SCOPA-AUT score（23.54±12.48） and domain scores in gastrointestinal（8.00±3.77） and urinary symptoms（6.28±3.51） compared to control subjects（P〈0.01）.There were significant correlations between the total score with UPDRS,Hoehn-Yahr scale or score of Schwab and England disability scale（P〈0.01 or 0.05）,and no correlation with duration or age（P﹥0.05）.Conclusions Autonomic dysfunction of PD increased significantly with disease severity.There were significantly negative correlation between the total score of SCOPA-AUT with the limb SSR amplitude（P〈0.05）in PD patients.SSR and SCOPA-AUT can act as an objective index to assess autonomic dysfunctions in patients with PD quantitatively.

关 键 词：帕金森病 自主神经功能障碍 交感神经皮肤反应 自主神经症状量表 

分 类 号：R742.5[医药卫生—神经病学与精神病学]