口腔白斑和癌组织中Smad4、Bcl-2的表达及其相关性研究  

The expression and their correlation of Smad4 and Bcl-2 in oral leukoplakia and cancer

作　　者：陈学升[1] 陈作良[1] 程筠[1] 郑晓斌[1] 

机构地区：[1]福建医科大学教学医院.厦门市口腔医院,福建厦门361003

出　　处：《临床口腔医学杂志》2009年第12期707-709,共3页Journal of Clinical Stomatology

摘　　要：目的:检测口腔白斑和癌组织中Smad4和Bcl-2的表达情况,探讨二者在口腔白斑的癌变过程中的变化及其相互关系。方法:免疫组织化学SABC法检测Smad4蛋白表达情况及Polymer法检测Bcl-2蛋白的表达情况。结果:Smad4蛋白在正常组织、白斑及癌组织中阳性表达率分别是100.0%、92.3%和33.3%,阳性表达差异有统计学意义(P﹤0.01);Bcl-2蛋白在正常组织中、白斑及癌组织中阳性表达率分别是30.0%、53.8%和100.0%,阳性表达差异有统计学意义(P﹤0.01);Smad4蛋白表达与Bcl-2蛋白表达呈负相关(r=-0.854,P<0.01)。结论:Smad4和Bcl-2可能参与了口腔癌变的过程;在鳞癌的发生发展过程中,Smad4缺失表达和Bcl-2的过表达两者可能单独或协同参与。Objective： To investigate the expression of Smad4 and Bcl-2 and their con＇elation in oral precancerous lesion and cancer. Method： SABC and polymer was used to detect the expression of Smad4 and Bcl-2. Result：The positive expression rate of Smad4 protein is 100 %,92.3 % and 33.3 % respectively in normal tissue,leukoplakia and cancerous tissue. The differences of them have statistical significance. （P 〈 0.01） ;The positive expression rate of Bel-2 protein is 30 %, 53.8 % and 100 % respectively in normal tissue,leukoplakia and cancerous tissue. The differences of them have statistical significance. （P 〈 0.01） ;The expression of Smad4 protein was negative correlated with that of Bcl-2 protein （r=-0.854, P 〈 0.01）. Conclusion： Smad4 and Bcl-2 may be associated with oral canceration; Either loss of Smad4 expression or overex- pression of Bcl-2 or all may be involved in oncogenesis and development of OSCCs.

关 键 词：口腔白斑 口腔鳞癌 SMAD4 BCL-2 

分 类 号：R781.5[医药卫生—口腔医学] R780.2[医药卫生—临床医学]