癌基因c-myc在喉癌组织中的表达及意义  

The expression of oncogene c-myc and its role on human laryngeal cancer

作　　者：龙小博[1] 胡双[1] 曹平平[1] 刘争[1] 甄宏韬[1] 崔永华[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科,武汉430030

出　　处：《临床耳鼻咽喉头颈外科杂志》2009年第24期1127-1129,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：湖北省科技厅攻关计划课题(No:2005AA401D96)

摘　　要：目的:检测癌基因c-myc在喉癌组织中的表达并探讨其意义。方法:采用实时定量PCR和SP免疫组织化学方法分别检测喉癌组织和癌旁正常组织癌基因c-myc mRNA和蛋白的表达水平。结果:与正常喉组织比较,癌基因c-myc mRNA和蛋白水平在不同分化程度的喉癌组织中表达均明显上调(P<0.05),其表达水平的高低与喉癌组织的分化程度成负相关。结论:癌基因c-myc在喉癌组织中高表达,可能参与了喉癌发生发展的过程,为喉癌的基因治疗提供了新靶点。Objective：To detect the expression of oncogene c-myc and explore its role on human laryngeal cancer.Method：The mRNA and of oncogene c-myc levels were detected in human laryngeal cancer tissues and laryngeal normal tissues by the means of real-time PCR and immunohistochemistry,respectively.Result：Compared with normal laryngeal tissues,the mRNA and protein levels of oncogene c-myc were both upregulated in laryngeal cancer tissues of all differentiation degree（P〈0.05）.Moreover,the level of c-myc was inverse correlated with the differentiation degree in human laryngeal cancer tissues.Conclusion：The oncogene c-myc is overexpressed in human laryngeal cancer tissues,and c-myc may play an important role in carcinogenesis and progression of human laryngeal cancer tissues. It may provide a new target for gene therapy of human laryngeal cancer.

关 键 词：癌基因 C-MYC 喉肿瘤 

分 类 号：R739.65[医药卫生—肿瘤]