低剂量三维适形放射治疗原发性颞叶癫痫  

Low dose sterotactic radiotherapy for primary temporal lobe epilepsy

作　　者：刘天星[1] 李安民[2] 刘爱军[2] 梁树立[2] 景丽[1] 

机构地区：[1]解放军总医院第304临床部放疗科,北京100048 [2]解放军总医院第304临床部神经外科,北京100048

出　　处：《军医进修学院学报》2009年第6期831-832,共2页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的观察低剂量的三维适形放疗（3DCRT）治疗原发性颞叶癫痫的疗效。方法2003年4月-2005年4月收治的13例原发性颞叶癫痫患者,用WinMRT-TPS优化治疗方案,以85%-90%等剂量计算,三维适形放疗隔日1次,共2次,总Dt12Gy。患者随访3-5年,评定疗效。结果治疗后6个月缓解6例,6-12个月缓解5例,2例无效。治疗后1年总有效率84.6%（11/13）,3年80.0%（8/10）,5年71.4%（5/7）。治疗后7例出现脑水肿,3例轻微头疼、恶心,9例局灶性脱发。结论低剂量三维适形放疗治疗原发性颞叶癫痫部分患者疗效良好,提示该方法是一种微创、有效的治疗方法。Objective To investigate the treatment effects of low dose sterotaetic radiotherapy for primary temporal lobe epilepsy. Methods 13 patients of primary temporal lobe epilepsy were treated two times （once every two days） by sterotactic radiotherapy with a total dose of 12Gy according to WinMRT-TPS treatment method. All patients had a follow-up period of 3-5 years. Results 6 patients had reduced seizure freguency in 6 months after treatment 5 patients had reduced seizure freguency in 6-12 months and 2 patients had no efficacy. The efficient rate was 84.6%（11/13） one year after treatment, 80.0%（8/13） 3 years after treatment, 71.4%（5/7） 5 years after treatment, respectively. After treatment 7 patients had transient brain edema, 3 patients had slight headache and nausea, and 9 patients had local lose hair. Conclusion Low dose sterotactic radiotherapy is safe and effective for primary temporal lobe epilepsy. This modality is minimal invasive and effective.

关 键 词：癫痫 放射治疗剂量 

分 类 号：R730.5[医药卫生—肿瘤]