配对胃癌组织中AIF的表达  

Expression of apoptosis inducing factor in matched gastric cancer tissue

作　　者：王昌正[1] 吴本俨[1] 黄海力[1] 尤纬缔[1] 

机构地区：[1]解放军总医院南楼消化科,北京100853

出　　处：《军医进修学院学报》2009年第6期878-880,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：解放军总医院苗圃基金(07MP35)

摘　　要：目的探讨凋亡诱导因子(apoptosis inducing factor,AIF)在无淋巴结转移的胃癌组织中的表达及其与临床病理特征的关系。方法构建胃癌组织芯片,应用免疫组化方法检测AIF在100例无淋巴结转移的胃癌组织以及配对的癌旁正常胃黏膜中的表达。分析AIF表达与胃癌临床病理的相关性。结果AIF在胃癌组织中表达阳性率为48%,在癌旁正常胃黏膜中仅在胃壁细胞中表达;胃癌组织中AIF的表达与肿瘤的组织类型、浸润深度、TNM分期及Lauren分型均无关(P>0.05)。结论AIF的表达量上调可能对胃癌的发生、发展起一定作用。Objective To study the expression of apoptosis inducing factor（AIF）in gastric cancer tissue without lymph node metastasis and its correlation with the clinicopathologic features of gastric cancer. Methods Gastric cancer tissue microarray was constructed and used to detect the expression of AIF in 100 gastric cancer tissue samples from patients without lymph node metastasis and in matched adjacent normal gastric mucosal tissue samples by immunohistochemistry. The correlation of AIF expression with clinicopathologic features of gastric cancer was analyzed. Results The positive AIF expression rate in gastric cancer tissue was 48%, and AIF was expressed only in gastric wall cells of the adjacent normal gastric mucosa. However, AIF expression in gastric cancer tissue was not correlated with the histological subtypes, invasion depth, TNM phases, and Lauren classification of gastric cancer（P〉0.05）. Conclusion Up-regulated AIF expression in gastric cancer tissue may play a role in the occurrence and development of gastric cancer.

关 键 词：凋亡诱导因子 胃肿瘤 组织芯片 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]