沥青工血清癌蛋白水平的分子流行病学研究  

Molecular Epidemiological Study on the Serum Oncoprotein in Workers Exposed to Coal Tar Pitch(CTP)

作　　者：王新朝[1] 吴逸明[1] 陈琛[1] 李志远[1] 徐玉宝[1] 

机构地区：[1]河南医科大学劳动卫生学教研室

出　　处：《中国公共卫生》1998年第10期601-602,共2页Chinese Journal of Public Health

基　　金：河南省科委;河南省教委;河南省卫生厅1997年度重点资助课题

摘　　要：为了解沥青工血清ｒａｓＰ２１癌蛋白水平，从分子水平阐明毒作用，用ＷｅｓｔｅｒｎＢｌｏｔｉｎｇ法对２４名沥青工和１２正常对照组血清Ｐ２１进行分子流行病学调查研究。结果：沥青工Ｐ２１均值（３５５８．７）明显高于对照（１２７０．７），差异有显著性；接触组沥青工中按工龄分组和按是否吸烟分组进行比较，均未发现组间Ｐ２１的显著性差异。此结果提示。In order to know the serum P21 oncoprotein levels in workers exposed to CTP who were recognized as the occupational pulmonary carcinoma risk population,the serum P21 levels in 24 workers exposed to CTP and in 12 normal cases were detected with the molecular analysis method of Western Blotting.The results showed that the mean P21 level(3558 7) of workers exposed to CTP was significantly higher than that of the normal controls(1270 70)(P<0 01).There were no P21 differences among different work ages and between the workers with or wihtout smoking history.It indicated that CTP can cause the increase of P21 oncoprotein level.

关 键 词：沥青工 血清 P21 分子流行病学 癌蛋白 

分 类 号：R73－31[医药卫生—肿瘤] R730.231.1[医药卫生—临床医学]