耐热性肝再生刺激因子治疗肝炎肝硬化的临床实验研究  

Clinical Study of the Effectiveness of Heatstable Hepatocyte Stimulating Substance

作　　者：吕洪敏[1] 韩涛[1] 王凤梅[1] 钱绍诚 

机构地区：[1]天津市第三中心医院,300170

出　　处：《天津医药》1998年第9期535-537,共3页Tianjin Medical Journal

摘　　要：观察耐热性肝细胞因子(HSHSS)的疗效,以肝细胞生长因子(HSS)作为对照。两组取肝硬化和(或)慢性肝炎病人各30例,疗程2～8周。平均4.5周。结果表明,两组治疗前后肝功能均明显改善(P<0.05)。在提高血浆白蛋白水平及改善凝血酶原活性方面,HSHSS优于HSS组。HSHSS的有效性弥补了HSS贮存、运输需要低温的缺点。Several years ago,a heatstable hepatocyte stimulating substance(HSHSS)was developed in our laboratory and the clinical study of its effectiveness was performed in 60 patients with cirrhosis of liver or chronic active hepatitis B,being divided into two groups, each 30 patients. Patients in group 1 were treated with HSHSS and in group 2 with unstable HSS as control. After 2 ~ 8 (mean 4.5) weeks treatment, the results were as follows: All patients in both groups got signifcantly better liver functions than before treatment(P < 0.05 ). But the prothrombin activity and blood albumin levels were significantly more improved in group 1 than those in group 2. The results suggested that HSS and HSHSS were both effective to improve liver functions in liver cirrhosis and chronic active hepatitis,and HSHSS was better than HSS. In addition,there was an advantage of its heat stability,HSHSS had no need for refrigeration.

关 键 词：肝炎 肝硬化 耐热性 肝细胞生长因子 HSHSS 治疗 

分 类 号：R575.205[医药卫生—消化系统]