手性拆分技术及其在手性药物合成中的应用新进展  

Application progress of novel optical resolution technologies in the chiral drugs

作　　者：杨千姣[1] 刘丹[1] 曲蕾[1] 吴族悌[1] 赵临襄[1] 

机构地区：[1]沈阳药科大学制药工程学院药物化学系,辽宁沈阳110016

出　　处：《中国药物化学杂志》2009年第6期429-435,462,共8页Chinese Journal of Medicinal Chemistry

摘　　要：手性拆分是获得手性药物的重要途径,该文对经典的结晶法拆分、动力学拆分和色谱分离法拆分等手性拆分方法的新进展进行综述,并介绍膜拆分法、萃取拆分法等新技术在手性药物合成中的应用。Up to date, optical resolution is the important approach to prepare chiral drugs. Classical optical resolution methods include crystallization resolution, kinetic resolution and chromatographic methods. New progresses of these methods are reviewed and the application of membranous resolution and extractive resolution in the preparation of chiral drugs are introduced in this paper.

关 键 词：手性药物 手性拆分 膜拆分法 萃取拆分 

分 类 号：R914[医药卫生—药物化学]