不对称aldol反应及其在天然产物全合成中的应用  

Asymmetric aldol reactions and their applications in the total synthesis of natural products

作　　者：鲁毅翔[1] 周玓[1] 马小双[1] 贾娴[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《中国药物化学杂志》2009年第6期452-462,共11页Chinese Journal of Medicinal Chemistry

摘　　要：不对称aldol反应是天然产物全合成领域中应用最为广泛的反应之一。该文重点介绍近5年来应用于天然产物全合成中的、由手性辅基及手性催化剂介导的不对称aldol反应。Asymmetric aldol reactions are considered to be one of the most widely used reactions, especially in the field of total synthesis of natural products. Herein, the research on chiral auxiliary or chiral catalyst mediated asymmetric aldol reactions and their applications in the total synthesis of natural products within recent five years are reviewed.

关 键 词：不对称ALDOL反应 手性辅基 手性催化剂 全合成 天然产物 

分 类 号：R914[医药卫生—药物化学]