30例乳腺癌患者级联激活的免疫细胞治疗后细胞免疫功能变化  

Changes of Cellular Immune Function in 30 Cases of Patients with Breast Cancer After Therapy of CAPRI

作　　者：王明鑫[1] 宋鑫[2] 邹天宁[1] 陈文林[1] 王建逵[1] 王龙强[1] 

机构地区：[1]昆明医学院第三附属医院乳腺病科,云南省乳腺癌临床研究中心,云南昆明650118 [2]昆明医学院第三附属医院生物治疗中心,云南昆明650118

出　　处：《昆明医学院学报》2009年第11期68-71,共4页Journal of Kunming Medical College

基　　金：昆明医学院研究生创新基金资助项目(KM2008J13)

摘　　要：目的观察乳腺癌患者CAPRI细胞治疗前后T淋巴细胞亚群的变化及其临床意义.方法采用流式细胞术(FCM)检测30例乳腺癌患者化疗6周期后接受CAPRI细胞治疗1周期前后的淋巴细胞亚群并进行对比研究.结果接受CAPRI细胞治疗1周期后乳腺癌患者的外周血中的CD3+细胞、CD4+细胞、NK细胞的数量与接受CAPRI细胞治疗前相比均有较明显的提高(P<0.05),而CD8+细胞的数量与接受CAPRI细胞治疗前相比没有较明显的改变(P>0.05).结论乳腺癌患者化疗结束后应用CAPRI细胞治疗对乳腺癌患者的细胞免疫功能具有明显改善作用.Objective To observe the changes of T-lymphocyte subsets of patients with breast cancer before and after therapy of CAPRI.Method By flow cytometry（FCM）,we detected the changes of T-lymphocyte subsets of 30 cases of patients with breast cancer who received 6 cycles of chemotherapy before and after one cycle of therapy of CAPRI and performed comparative studies.Result Compared to pretherapy of CAPRI,after one cycle of therapy of CAPRI,there was significant increase in the number of CD3＋ cells,CD4＋ cells,NK cells in the peripheral blood of the patients with breast cancer（P0.05）,and there was no significant change in the number of CD8＋ cells in the peripheral blood of the patients（P0.05）.Conclusions The therapy of CAPRI can improve significantly the cellular immune function of the patients with breast cancer after chemotherapy.

关 键 词：乳腺癌 级联激活的免疫细胞 细胞免疫 生物治疗 

分 类 号：R737.9[医药卫生—肿瘤]