中西医结合治疗对重症急性胰腺炎患者血清抵抗素的影响:随机对照临床试验  

Influence of integrated traditional Chinese and Western medicine therapyon serum resistin levels in patients with severe acute pancreatitis:a randomized controlled trial

作　　者：马悦[1] 黄宗文[1] 夏庆[1] 薛平[1] 郭佳[1] 魏宏强[1] 陈燕[1] 何馥倩[1] 程征宇[1] 林子琦[1] 

机构地区：[1]四川大学华西医院中西医结合科,四川成都610041

出　　处：《中西医结合学报》2009年第12期1134-1138,共5页Journal of Chinese Integrative Medicine

基　　金：四川省中医药管理局基金资助项目(No.2007B03);四川省人事厅人才培养计划基金资助项目(No.07SRC-13);国家科技支撑计划资助项目(No.2006BA104A15)

摘　　要：背景:抵抗素在重症急性胰腺炎(severe acute pancreatitis,SAP)中的含量明显增高,抵抗素有望成为评价急性胰腺炎严重程度的新的标记物。目的:探讨中西医结合疗法对 SAP 患者血清抵抗素水平的影响。设计、场所、对象和干预措施:采用前瞻性随机对照研究,确定病例入选标准,病例均源干四川大学华西医院中西医结合科。所有满足入选标准的病人在签署知情同意书后进入研究程序,并按照随机号分别进入中西医结合治疗组和安慰剂对照组,治疗组13例,对照组15例。中西医结合治疗组给予西医内科基础治疗联合中医药治疗,安慰剂对照组除给予安慰剂外,其余西医内科基础治疗同中西医结合治疗组。主要结局指标:依次于入院时及入院后第1、3、5、7天抽取两组患者静脉血,观察血清抵抗素水平的变化并比较两组患者的血清抵抗素水平。结果:两组患者入院时血清抵抗素水平均明显高于正常水平,治疗组和对照组比较,差异无统计学意义(P>0.05)。治疗组第1、3、5、7天测得的抵抗素水平分别为(3.29±1.66)、(3.71±1.05)、(3.08±1.47)、(3.62±1.67)μg/L,对照组分别为(5.16±1.93)、(5.07±1.53)、(4.88±1.47)、(5.12±1.48)μg/L。治疗组血清抵抗素水平均低于对照组(P<0.05)。结论:应用中西医结合疗法能降低 SAP 患者血清抵抗素浓度,但具体作用机制有待进一步研究。Background： Resistin level is high in patients with severe acute pancreatitis （SAP）, and resistin is expected to be a new marker for evaluating the severity of acute pancreatitis. Objective： To explore the influence of integrated traditional Chinese and Western medicine therapy on serum resistin leveis in SAP patients. Design, setting, participants and interventions： Twenty-eight SAP patients meeting inclusion criteria from Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University were included, and the patients were randomly divided into treatment group and placebo group. There were 13 patients in the treatment group and 15 patients in the placebo group. Patients in the treatment group were given traditional Chinese herbal medicine in addition to the conventional treatment. Patients in the placebo group were given placebo in addition to the conventional treatment.Main outcome measures： The serum resistin levels on admission, and days 1, 3, 5, and 7 after the admission were detected.Results： The serum resistin levels on admission in all the patients were higher than normal level, and there was no significant difference between the two groups （P〉0.05）. On days 1, 3, 5, and 7 after admission, the resistin Levels in the treatment group were （3. 29±1.66） μg/L, （3.71±1.05） μg/L, （3.08±1.47） μg/L and （3.62±1.67） μg/L, and in the control group （5. 16±1. 93） μg/L, （5.07±1.53） μg/L, （4. 88± 1.47） μg/L and （5.12±1.48） μg/L, respectively. The resistin levels were lower in the treatment group than in the control group （P〈0.05）, Conclusion： Serum resistin level in SAP patients can be decreased by integrated traditional Chinese medicine and Western medicine therapy.

关 键 词：重症急性胰腺炎 抵抗素 中西医结合 安慰剂 前瞻性研究 随机对照试验 

分 类 号：R576[医药卫生—消化系统]