谷氨酸单钠对大鼠垂体促性腺激素细胞的影响  

Effect of Monosodium Glutamate on GTH Pituicyte in Rats

作　　者：刘冬梅[1] 杨荪 王蓬文[2] 周以健[2] 

机构地区：[1]首都医科大学附属北京天坛医院内科 [2]首都医科大学病理解剖学教研室

出　　处：《首都医科大学学报》1998年第3期213-216,共4页Journal of Capital Medical University

摘　　要：给新生期大鼠皮下注射１０％谷氨酸单钠（ＭＳＧ），观察其青春期（５２日龄）及成年期（１００日龄）的垂体及黄体生成素（ＬＨ）细胞的变化。结果：青春期和成年期给药组大鼠的垂体质量分别为（３．２６±０．５１）ｍｇ和（５．２１±０．７２）ｍｇ，显著低于对照组的（８．４６±０．８１）ｍｇ和（１２．０４±１．２３）ｍｇ（Ｐ＜０．０１）；给药组的ＬＨ细胞面积（像素值）分别为９９８．００±１６１．５６和１１０５．５６±２１９．８３，显著小于对照组的１６６２．３０±１４１．４６和１８９２．１１±２１２．２９（Ｐ＜０．０１）。但各期给药组单个细胞内ＬＨ含量与对照组均无显著性差异（Ｐ＞０．０５）。血清ＬＨ及卵泡刺激素（ＦＳＨ）的浓度给药组各期均显著低于对照组（Ｐ＜０．０１）。给药组弓状核神经细胞明显减少，分布稀疏。The neonatal rats were injected subcutaneously with 10% monosodium glutamate(MSG). The development of rat pituitary gland and LH pituicyte were observed on the 52th day (puberty) and 100th day (adult). The results showed:The pituitary weights on 52th and 100th day were ( 3.26± 0.51) mg and (5.21±0.72) mg in MSG group respectively. They decreased significantly as compared with control group( P <0.01), (8.46±0.81) mg and (12.04±1.23) mg respectively. The mean area of LH pituicytes on 52th day and 100th day were 998.00±161.56 and 1 105.56± 219.83. They decreased remarkably as compared with control group( P <0.01), 1 662.30±141.46 and 1 892.11±212.29 respectively. However, LH content of individual LH pituicyte in MSG group had no significant differences as compared with that in control group( P >0.05). The serum concentrations of LH and FSH were significantly lower in MSG group than those of control group on both ages. A striking reduction in the number of neurons in the arcuate nucleus(ARC) were noted . Thus, MSG can depress the development and function of GTH pituicytes .

关 键 词：谷氨酸单钠 促性腺激素细胞 黄体生成素 

分 类 号：Q453[生物学—生理学]