浙江省丽水市人民医院246例就诊妇女中人乳头瘤病毒感染及亚型分布研究  

Human papillomavirus infection and subtype distribution among 246 female visitors to Lishui People's Hospital in Zhejiang

作　　者：闫贵贞[1] 郑红枫[1] 金淑美[1] 夏伟兰[1] 

机构地区：[1]浙江省丽水市人民医院妇产科,浙江丽水323000

出　　处：《疾病监测》2009年第11期843-845,共3页Disease Surveillance

摘　　要：目的了解人乳头瘤病毒(HPV)在浙江省丽水市人民医院妇科门诊就诊患者中的感染情况及其亚型分布。方法应用基因芯片技术对2006年10月至2007年6月在该院就诊的246例患者进行HPV23种基因型检测。结果246例患者中共检出HPV阳性者125例,阳性率为50.8%,其中HPV-16型54例(阳性率为21.9%),HPV-58型21例(阳性率为8.5%),其余型别为50例(阳性率为20.3%),2种型别以上HPV阳性39例(阳性率为15.8%),单种型别HPV阳性86例(阳性率35.0%)。同时,在55例宫颈上皮内瘤变(CIN)患者中HPV阳性39例(阳性率70.9%),在12例宫颈癌中HPV阳性11例(阳性率91.7%),在13例宫颈尖锐湿疣中HPV阳性11例(阳性率84.6%)。结论应积极控制HPV感染及有效治疗CIN在妇女宫颈癌的防治中具有重要意义。Objective To determine the situation of infection and subtype distribution associated with human papillomavirus（HPV） among female visitors to the gynecologic clinic of Lishui People＇s Hospital. Methods Cervical swabs collected from 246 patients from October 2006 to June 2007 were subject to gene-chip genetic detection invovling 23 genotypes of HPV. Rseults A total of 125 （50.8 % ） out of 246 women were identified as HPV-positive, including 54 （21.9%） of HPV-16, 21 （8.5%） of HPV-58 and 50 （20.3%） of others. Thirty-nine subjects were found to have been infected with two or more subtypes of HPV （ 15.8% ）, and 86 with one sole subtype （35.0%）. Meanwhile, 39 HPV-positive patients were identified among 55 subjects that had cervical intraepithelial neoplasia （C/N）, 11 HPV- positive ones among 12 with cervical cancer, and 11 HPV-positive ones among 13 with cervical condyloma acuminata. Conclusion It is key to prevention and control of HPV infection in conjunction with appropriate management of CIN, which plays a significant part in the management of cervical cancer.

关 键 词：人乳头瘤病毒 基因芯片技术 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]