沥青工、焦炉工血清 ras p21 水平的研究  

Studies on the Ras p21 Levels in Workers Exposed to Coal Tar Pitch and Coke Oven Volatiles

作　　者：王新朝[1] 吴逸明[1] 陈琛[1] 

机构地区：[1]河南医科大学公共卫生学院

出　　处：《卫生研究》1998年第5期292-293,共2页Journal of Hygiene Research

基　　金：河南省卫生厅与河南省教委资助

摘　　要：为了解职业性肺癌高发人群沥青工和焦炉工血清ｒａｓｐ２１癌蛋白水平，从分子水平阐明毒物作用于机体后的反应；用ＷｅｓｔｅｒｎＢｌｏｔｉｎｇ法对２４名沥青工、２５名焦炉工和１２名正常对照组血清ｐ２１水平进行了研究。结果发现接触组ｐ２１均值（３６６８．６）明显高于对照（１２７０．７，Ｐ＜０．０１）。按工种分层分析，沥青工和焦炉工血清ｐ２１均值明显高于对照组（Ｐ＜０．０１）；焦炉工中的炉顶工ｐ２１水平明显高于其它工种（Ｐ＜０．０５）；接触组按工龄分组、是否吸烟分组进行比较，未发现ｐ２１的显著性差异。此结果提示。To study the effects of serum p21 levels on the health of coal tar pitch(CTP) and coke oven volatiles (COV) workers recognized as the high risk population of pulmonary carcinoma,serum p21 levels among 24 cases of CTP workers,25 cases of COV workers and 12 cases of normal control were detected with the method of Western Blotting.The results showed that the mean serum p21 level in exposed group was significantly higher than that in the normal control (3668 vs 12707,P<0001).In the COV workers,serum p21 level in coke furnace workers was remarkly higher than that in the workers with other types of work.There were no differences for p21 among workers with different work years and between workers with or without smoking history.It indicates that CTP and COV can cause the p21 protein level increse in the occupational population.

关 键 词：沥青工 焦炉工 血清 P21 癌蛋白 肺肿瘤 

分 类 号：R730.231.1[医药卫生—肿瘤] R135.1[医药卫生—临床医学]