孕中期唐氏综合征筛查二联与三联结果比对分析  

Comparison of dual-marker and triple-marker prenatal screening on Down syndrome

作　　者：陈志央[1] 张檀[1] 毛芬菁[1] 庄丹燕[1] 

机构地区：[1]宁波市妇女儿童医院,浙江315012

出　　处：《中国预防医学杂志》2009年第12期1108-1110,共3页Chinese Preventive Medicine

摘　　要：目的比较孕中期母血清二联筛查(AFP、Freeβ-hCG)与三联筛查(AFP、Freeβ-hCG和uE3)的临床有效性。方法应用时间分辨荧光免疫方法(DELFIA)检测36025例孕中期母血清标记物AFP、Freeβ-hCG和uE3,分别用二联与三联方案利用Risk2T风险分析统计软件计算胎儿发生唐氏综合征(Downsyndrome,DS)的危险概率,并随访妊娠结局。结果36025例孕妇中用二联方案检出DS高风险1242例,占筛查总数的3.45%;用三联方案检出DS高风险1272例,占筛查总数的3.53%,其中有581例二联和三联均为高风险,但有691例二联与三联高风险不对应。结论孕中期应用母血清二联和三联方案进行产前筛查均可有效地减少出生缺陷的发生,三联方案的临床有效率更高。Objective To evaluate the clinic value of dual-marker （ AFP, free β-hCG） and triple-marker （ AFP, free β-hCG, uE3 ） in prenatal screening on Down syndrome during second trimester of pregnancy. Methods The serum AFP, free β-hCG and uE3 in 36 025 pregnant women were determined with time-resolved fluorometric assay, then the results were analyzed by Risk 2T software to determine the fetal risk of Down syndrome. Results Among 36 025 women, 1 242 （ 3.45% ） were considered as high risk of Down syndrome by dual-marker screening; 1 272 （3.53%） with a high risk of Down syndrome by triple-marker screening; 581 cases with a high risk by both methods, but the results of 691 cases were different with the two methods. Conclusion ＇ Both methods can be used efficiently in the maternal serum screening to reduce the birth defects. However, triple-marker screening is more effective.

关 键 词：产前筛查 唐氏综合征 二联 三联 出生缺陷 

分 类 号：R714.55[医药卫生—妇产科学]