口服核苷酸降血脂作用的实验研究  

Study on the hypolipidemic effects of dietary nucleotides

作　　者：赵明[1] 刘志刚[1] 张佳丽[1] 梁江[1] 赵海峰[1] 李琼[1] 张召锋[1] 王军波[1] 李勇[1] 

机构地区：[1]北京大学公共卫生学院营养与食品卫生学系,100191

出　　处：《中国预防医学杂志》2009年第12期1124-1126,共3页Chinese Preventive Medicine

摘　　要：目的研究口服核苷酸对实验性高脂血症大鼠血脂水平的影响。方法选用60只健康雄性SD大鼠分成正常对照、高脂模型对照和0.04,0.16,0.64g/kg体重核苷酸组,正常对照组大鼠饲喂普通饲料,高脂模型和核苷酸组大鼠饲喂高脂饲料。核苷酸组大鼠以灌胃方式给予不同剂量的核苷酸(1ml/100g)45d,测定血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇含量。结果摄入核苷酸45d后,0.04,0.16,0.64g/kg体重组大鼠血清总胆固醇(TC)分别为(3.14±1.45),(3.65±1.58),(3.14±1.70)mmol/L,0.04g/kg体重组及0.64g/kg体重组与高脂模型对照组(4.26±1.96)mmol/L相比显著降低;甘油三酯(TG)含量分别为(0.93±0.53),(0.93±0.44),(0.72±0.38)mmol/L,0.64g/kg体重组与高脂模型对照组〔(1.29±0.49)mmol/L〕相比显著降低;高密度脂蛋白胆固醇(HDL-C)分别为(1.19±0.31),(1.22±0.31),(1.26±0.36)mmol/L,与高脂模型对照组〔(1.09±0.16)mmol/L〕相比差异无统计学意义。结论口服核苷酸具有一定的辅助降血脂功能,并提示其对动脉粥样硬化的发生具有一定的预防作用。Objective To determine the effects of dietary nucleotides （NT） on serum lipids in hyperlipidemic rats. Methods Sixty healthy male SD rats were divided into 5 groups, which were normal control （NC） group, hyperlipidemic model control （HC） group and 0. 04, 0. 16, 0. 64 g/kg bw NT groups. NT were orally administered by gavage to rats in NT groups for 45 consecutive days （ 1 ml/100 g bw per day）, and the control rats were given vehicle only. All animals except NC rats were fed with a high fat diet. The levels of serum total cholesterol （ TC ）, triglyceride and low-density lipoprotein cholesterol （ LDL-C ） were measured. Results The levels of serum total cholesterol （ TC ） in 0. 04, 0. 16, 0. 64 g/kg bw NT groups were （ 3. 14 ± 1.45） mmol/L, （3.65 ± 1.58） mmol/L, （3.14±1.70） mmol/L respectively, and the groups of 0.04 and 0.64g/kg bw had significantly lower level than that in HC group [ （4. 26 ± 1.96） mmoL/L] ; Triglycerlde （TG） level in 0. 64 g/kg bw NT group [ （0. 72 ±0.38） mmol/L] were reduced significantly compared with that in HE group [ （ 1.29 ±0. 49） mmo]/L]. The LDL-C levels didn＇t have significant differences among groups. Conclusion Dietary nucleotides have a moderate lipid-lowering effects, indicatrng that it may play a preventive role in hyperlipidemia.

关 键 词：核苷酸 高脂血症 降血脂 

分 类 号：R965.1[医药卫生—药理学]