洛伐他汀对颈动脉粥样硬化斑块、血脂及血清C-反应蛋白水平的影响  

Effect of Lovastatin on carotid atherosclerotic plaques, levels of blood lipid and serum C-reactive protein

作　　者：尹继君[1] 林峰[1] 王高临[1] 孟范文[1] 王新强[1] 彭玉华[1] 许光霞[1] 

机构地区：[1]泰山医学院附属聊城二院神经内科,252601

出　　处：《临床神经病学杂志》2009年第6期458-460,共3页Journal of Clinical Neurology

摘　　要：目的观察洛伐他汀对脑梗死患者颈动脉粥样硬化斑块、血脂及血清C-反应蛋白(CRP)水平的影响。方法120例脑梗死合并颈动脉粥样硬化斑块患者随机分为洛伐他汀组和对照组。两组在低脂饮食的基础上,洛伐他汀组口服洛伐他汀20mg每日1次,共6个月;观察两组治疗8周及6个月时颈动脉粥样硬化斑块积分、血清CRP及血脂水平的变化。结果(1)治疗6个月时,洛伐他汀组颈动脉粥样硬化斑块积分(4.20±3.77)明显低于治疗前(4.77±2.31)及对照组(6.86±1.89)(均P<0.05);(2)治疗8周时,洛伐他汀组血清CRP水平[(6.37±2.16)mg/L]明显低于治疗前[(16.35±5.18)mg/L]及对照组[(16.30±4.84)mg/L](均P<0.05);(3)与治疗前及对照组比较,治疗8周及6个月时,洛伐他汀组血总胆固醇、三酰甘油及低密度脂蛋白胆固醇水平明显降低,高密度脂蛋白胆固醇明显升高(均P<0.05)。结论长期服用洛伐他汀可稳定甚至缩小颈动脉粥样硬化斑块,降低CRP及血脂水平,有助于预防脑卒中复发。Objective To observe the effect of Lovastatin on carotid atherosclerotic plaque （ CAP）, levels of blood lipid and serum C-reactive protein（CRP） in patients with cerebral infarction （C1）. Methods 120 CI patients with CAP were randomly divided into Lovastatin group and control group. At the basic of low fit diet for the two groups, Lovastatin was taken with 20 mg once a day for 6 months in Lovastatin group. Then, the changes of paque score,the levels of CRP and blood-lipid were observed 8 weeks and 6 months after treatment. Results （ 1 ）6 months later, the plaque score（4.20 ±3.77） in the Lovastatin group was significantly lower than pro-treatment（4.77 ± 2. 31 ） and the control group（6.86 ± 1.89） （ all P 〈 0.05 ）. （2） 8 weeks later, the level of serum CRP [ （ 6.37 ± 2. 16） mg/L] in the Lovastatin group was markedly lower than that pro-treatment [ （ 16.35 ± 5.18 ） mg/L] and the control group[ （ 16.30 ± 4. 84） mg/L ] （ all P 〈 0. 05 ）. （ 3 ） 8 weeks and 6 months later, compared to pro-treatment and the control group, the levels of total cholesterol , triacylglycerol and low density lipoprotein cholesterol in the Lovastatin group were obviously reduced, the level of high density lipoprotein cholesterol was obviously higher （ all P 〈 0.05 ）. Conclusions CAP can be stable, even reduced, and the level of blood-lipid can be decrease by take Lovastatin for long-term in patient with CAP. Which is helpful to prevente the recurrence of stroke.

关 键 词：洛伐他汀 脑梗死 动脉粥样硬化 血脂 C-反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]