头颈部血管肉瘤21例临床分析  

Angiosarcoma of the Head and the Neck: Clinical Analysis of 21 Cases

作　　者：黄亮[1] 高明[2] 张艳[2] 

机构地区：[1]天津医科大学 [2]天津医科大学附属肿瘤医院甲状腺颈部肿瘤科

出　　处：《中国肿瘤临床》2009年第23期1343-1345,共3页Chinese Journal of Clinical Oncology

摘　　要：目的：探讨头颈部血管肉瘤的临床表现和分期、治疗与预后的关系。方法：回顾性分析1993年1月～2008年1月天津医科大学附属肿瘤医院收治的21例头颈部血管肉瘤患者的临床及随访资料，通过对所有患者病历资料的研究，结合国内外相关文献报道，讨论头颈部血管肉瘤的临床表现和分期、治疗与预后的关系，肿瘤分期依据AJCC2002年第六版软组织肉瘤分期标准。生存率用Kaplan—Meier法计算，用Log—rank法进行生存曲线比较。结果：21例中非综合治疗10例，综合治疗11例。GTNM分期Ⅰ期6例，Ⅱ期3例，Ⅲ期1例，Ⅳ期11例，总生存率1年为72.2％，3年为41.3％，5年为27．5％，10年为13．8％，出现复发或转移的中位时间为4个月。局部复发12例，占57．1％，远处转移11例，占52．4％，转移部位依次为淋巴结5例，肺4例，肝脏1例，骨1例。血管肉瘤极易误诊，诊断需有经验的病理科医师配合免疫组织化学法检验。不同的治疗方式（Χ^2=8．31，P=0．004）和肿瘤分期（Χ^2=9．74，P=0．002）与预后相关。结论：头颈部血管肉瘤临床上尚未有统一的治疗方案，生物治疗已应用于临床，术前综合治疗具有积极意义，但总体预后仍不理想，肿瘤的分期是影响预后的重要因素，以手术为主的综合治疗可以提高患者的生存率。Objective： To study the clinical manifestations of the head and neck angiosarcoma and the relationship of the staging with clinical treatment and prognosis. Methods： The clinical data of 21 patients with head and neck angiosarcoma treated in our hospital between January 1993 and January 2008 were retro- spectively analyzed. By studying the medical records of all patients and reviewing the related literatures, we discussed the clinical manifestations of these patients and the relationship of staging with clinical treatment and prognosis of head and neck angiosarcoma based on soft tissue sarcoma staging of AJCC2002＇ 6th. SPSS 17.0 software was used for statistical analysis. We calculated the survival rate using Kaplan-Meier method and compared the survival curves using log rank test. Results： Among these 21 cases, 10 were treated with non-combined treatment, and the other 11 cases were treated with combined treatment. There were 6 stage Ⅰ cases, 3 stage Ⅱ cases, 1 stage Ⅲ case, and 11 stage Ⅳ cases. The 1-, 3-, 5- and 10-year total survival rates were 72.2%, 41.3%, 27.5% and 13.8%, respectively. The average time of recurrence or metastasis was 4 months. Twelve cases had local recurrence （accounting for 57.1%）, and 11 cases had distant metastasis （accounting for 52.4%）. The metastatic sites included lymph node in 5 cases, lung in 4 cases, liver in 1 case, and bone in 1 case. Different treatment modalities （Χ^2=8.31, P=0.004） and tumor staging （Χ^2=9.74, P= 0.002） were prognostic factors. Conclusion： There are no unified treatment strategies for angiosarcoma of the head and the neck. The overall prognosis is still not ideal. Biological treatment has been applied to clinical practice. Preoperative combined treatment has positive results. Tumor staging is an important factor affecting the prognosis. Surgery-based combined treatment can improve patient survival.

关 键 词：头颈部肿瘤 血管肉瘤 综合疗法 预后 

分 类 号：R739.91[医药卫生—肿瘤] R197.32[医药卫生—临床医学]