胶质瘤中FGFR1OP和p57／Kip2蛋白的临床意义  

Clinical Significance of FGFR1OP and p57 （Kip2） Proteins in Gliomas： An Immunohistochemical Study

作　　者：谭永刚[1] 郑伟[1] 王浩[2] 邹华伟[1] 单风平[3] 

机构地区：[1]中国医科大学附属盛京医院肿瘤科,沈阳市110004 [2]北京通州区潞河医院神经外科 [3]中国医科大学免疫学教研室

出　　处：《中国肿瘤临床》2009年第23期1367-1369,共3页Chinese Journal of Clinical Oncology

基　　金：本文课题受辽宁省自然科学基金资助（编号：2006305007）

摘　　要：目的：探讨FGFR1OP和p57／Kip2在胶质瘤发生、发展中的作用和临床意义。方法：对中国医科大学附属盛京医院和北京通州区潞河医院的54例胶质瘤手术切除标本，采用sP法进行免疫组织化学染色。检测FGFR1OP和p57／Kip2的表达情况，分析其与胶质瘤临床病理各参数的相关性，并评价其临床意义。结果：FGFR1OP和p57／Kip2在胶质瘤中的阳性表达率分别为66．7％和44．4％，且随着胶质瘤的恶性程度不同表现出显著性差异（P〈0．05），FGFR1OP在高度恶性胶质瘤（Ⅲ～Ⅳ级）中的OD值为0．131±0．010，高于在低度恶性胶质瘤（Ⅰ～Ⅱ级）中的OD值（0．118±0．010），两者有显著统计学差异（P=0．000）。p57／Kip2在高度恶性胶质瘤（Ⅲ-Ⅳ级）中的OD值（0．156±0．008），低于在低度恶性胶质瘤（Ⅰ～Ⅱ级）中的OD值（0．165±0．006），两者有显著统计学差异（P=0．014）。Pearson相关系数检验分析提示FGFR1OP和p57／Kip2之间呈负直线相关（r=-0．732，P〈0．01）。结论：FGFR1OP的高表达与p57／Kip2的低表达可能参与胶质瘤的生长、分化和进展，提示预后不良。Objective： To investigate the effects of FGFR1OP and p57/Kip2 proteins on the genesis and progression of gliomas and their clinical significance. Methods： The expression of FGFR1OP and p57/Kip2 in 54 glioma specimens was detected by SP immunohistochemical technique. The relationship between the expression levels of those proteins and various clinical pathologic factors was evaluated. Results： The expression of FGFR1OP and p57/Kip2 was found in 66.7% and 44.4% gliomas, respectively. The OD value of FGFR1OP was 0.131±0.010 in high grade gliomas, and 0.118±0.010 in low grade ones, with a statistical significance （t=-5.497, P=0.000）, showing that higher expression of FGFRIOP was significantly associated with gloma cell differentiation. The OD value of p57/Kip2 was 0.156±0.008 in high grade gliomas, and 0.165±0.006 in low grade ones, with a statistical significance （t=0.296, P=-0.014）, showing that lower p57/Kip2 expression was correlated with high grade gliomas. FGFR1OP was negatively correlated with p57/Kip2 in gliomas （r=-0.732, P〈0.01）. Conclusion： Increased expression of FGFRIOP and/or decreased expression of p57/Kip2 may play an important role in the genesis and progression of gliomas and may indicate a poor prognosis.

关 键 词：胶质瘤 FGFR1OP p57/Kip2 

分 类 号：R739.41[医药卫生—肿瘤] R734.2[医药卫生—临床医学]