ω-3多不饱和脂肪酸对胃肠道恶性肿瘤患者术后炎症反应和营养状态的影响  

Effect of ω-3 Polyunsaturated Fatty Acid on Inflammatory Response and Nutritional State of Patients with Gastrointestinal Malignancies after Operation

作　　者：刘流[1] 庄文[1] 陈忠[2] 

机构地区：[1]四川大学华西医院胃肠外科中心,成都610041 [2]四川大学华西第二医院儿科,成都610041

出　　处：《中国普外基础与临床杂志》2009年第12期964-967,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：四川省科技厅基金项目资助(项目编号:07FG002-032)~~

摘　　要：目的研究ω-3多不饱和脂肪酸对胃肠道恶性肿瘤患者术后炎症反应和营养状态的影响。方法将华西医院胃肠外科中心2009年2月1日至6月1日收治的40例胃肠道恶性肿瘤患者随机分为对照组和实验组各20例。术后2组连续行7d肠外营养支持治疗,实验组每天加用ω-3多不饱和脂肪酸10g。术前、术后第2天及术后第8天分别抽血检测炎症反应指标(包括白细胞、中性粒细胞和C反应蛋白水平)和营养状态指标(包括总蛋白、白蛋白、前白蛋白、转铁蛋白和淋巴细胞水平)以及手术前、后体重变化(体重差)。结果2组患者的基线一致,具有可比性(P>0.05)。术后第2天2组患者各项炎症反应指标和营养状态指标水平比较,差异均无统计学意义(P>0.05);至术后第8天,实验组的中性粒细胞和C反应蛋白水平均明显低于对照组,淋巴细胞水平明显高于对照组,差异有统计学意义(P<0.05)。2组患者的体重差比较差异无统计学意义(P>0.05)。结论ω-3多不饱和脂肪酸能够有效减轻胃肠道恶性肿瘤患者术后的炎症反应,改善患者的术后营养状态。Objective To research the effect of ω-3 polyunsaturated fatty acid （PUFA） on inflammatory response and nutritional condition after operation for patients with gastrointestinal malignancies.Methods Forty patients with gastrointestinal malignancies were included in this study from February 1st,2009 to June 1st,2009.Forty cases were randomly allocated to experimental group （20 cases） and control group （20 cases）.Parenteral nutrition was conducted in continuous 7 days after operation.Comparing with control group,a dose of 10 g of ω-3 PUFA was given to experimental group every day in 7 days after operation in addition. Blood samples were gained before operation, the 2nd and 8th day after operation respectively to measure relative indexes about inflammatory response （WBC, neutrophilic granulocyte and C reaction protein） and nutrition （total protein, albumin, prealbumin, siderophilin and lymphocyte）. Reduction of body mass was also recorded. Results The baseline between experi- mental group and control group was comparable （P〉0. 05）. The levels of indexes about inflammatory response （WBC, neutrophilic granulocytem and C-reaction protein） and nutrition （total protein, albumin, prealbumin, siderophilin and lymphocyte） between experimental and control group did not reach statistically significant difference in the 2nd day after operation （P〉0.05）. The levels of neutrophilic granulocyte and C reaction protein in experimental group were lower than those of control group, and the level 05 lymphocyte in experimental group was higher than that of control group in the 8th day after operation, and all of them reached statistical significance （P〈0.05）. There was no statistical different in reduction of body mass between experimental group and control group, Conclusion ω-3 PUFA can depress the excessively inflammatory reaction and improve the nutritional condition of patients with gastrointestinal malignancies after operation.

关 键 词：Ω-3多不饱和脂肪酸 胃癌 结直肠癌 炎症反应 营养 

分 类 号：R735[医药卫生—肿瘤] R459.3[医药卫生—临床医学]