Glasgow预后分数与结直肠癌近期疗效  

Evaluate Glasgow Prognostic Score on Short-Term Prognosis of Colorectal Cancer

作　　者：刘丹[1] 汪晓东[2] 邓磊[1] 吕东昊[1] 董慧[1] 牛洁[1] 纳飞飞[1] 李立[2] 

机构地区：[1]四川大学华西临床医学院/华西医院MCQ团队,成都610041 [2]四川大学华西医院胃肠外科中心,成都610041

出　　处：《中国普外基础与临床杂志》2009年第12期1037-1041,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：四川省卫生厅科研课题(项目编号:090356)~~

摘　　要：目的探讨结直肠癌患者Glasgow预后分数(Glasgow prognostic score,GPS)与短期预后的关系。方法前瞻性纳入2009年4～6月期间经病理诊断为结直肠癌的住院患者。所有患者均于术前3d与术后1d测定血清C反应蛋白及白蛋白水平,并以此计算术前及术后的GPS分值,分析GPS与结直肠癌患者短期预后的关系。结果本研究共纳入结直肠癌患者38例。术前GPS与病理M分期(P=0.007)和TNM分期(P=0.013)有关,与病理T分期及N分期无关(P>0.05);术后GPS与病理T、N、M分期与TNM分期均无关(P>0.05)。术前及术后GPS与结直肠癌患者术后生存质量和术后并发症发生情况均无关(P>0.05)。结论术前GPS与结直肠癌病理M分期与TNM分期有关。机体炎症反应可能不是结直肠癌患者术后近期预后的决定性因素。Objective To determine the relationships between the preoperative and postoperative Glasgow prognostic score （GPS） and short-term prognosis in colorectal cancer.Methods Patients pathologically verified colorectal cancer were prospectively enrolled at West China Hospital of Sichuan University from April 2009 to June 2009.C-reactive protein （CRP） and albumin （Alb） were examined on the third day before operation and the first day after operation.We calculated the value of GPS and analyzed the relationships between GPS and short-term prognosis. Results This study enrolled 38 patients. Preoperative GPS was significantly related with pathological M stage （P 0.007） and TNM stage （P=0.013）, and was not related withT stage and N stage （P〉0.05）. Postoperative GPS was not related with pathological T, M, N and TNM stages （P〉0.05）. Moreover, there was no relationship between GPS and postoperative quality of life or complications （P〉0.05）. Conclusions Preoperative GPS correlates with pathologically M stages and TNM stages. Systematic inflammatory response maybe not the determinant factor for the short-term prognosis of patients with colorectal cancer.

关 键 词：结直肠癌 Glasgow预后分数 术前评估 预后 

分 类 号：R735.37[医药卫生—肿瘤]