动态磁敏感对比增强磁共振成像在脑肿瘤术前评估中的应用  

Application of Dynamic Susceptibility Contrast-Enhanced MR Imaging in Evaluation of Brain Tumor after Operation

作　　者：朱记超[1,2] 娄明武[2] 张方璟[3] 胡卫东[2] 范义[2] 陈燕萍[1] 

机构地区：[1]南方医科大学南方医院影像中心,广东广州510515 [2]深圳市龙岗中心医院介入影像科 [3]深圳市妇幼保健院放射科

出　　处：《实用放射学杂志》2009年第12期1698-1702,共5页Journal of Practical Radiology

摘　　要：目的评价动态磁敏感对比增强（DSC）磁共振成像技术在脑肿瘤术前评估中的应用价值。方法经病理证实的41例脑肿瘤患者，其中，高级别胶质瘤8例，低级别胶质瘤16例，转移瘤7例，脑膜瘤10例，使用3.0TMR扫描仪进行静脉团注钆喷替酸葡甲胺（Gd-DTPA）的DSC灌注检查，原始图像分析处理后分别获取肿瘤实性区域、瘤周1cm及2cm区域血流灌注指标平均rCBVmax比值及平均rCBFmax比值。所得数据经统计学处理，并用Pearson相关分析法来分析两灌注指标的相关性。结果在肿瘤实性区域，低级别胶质瘤组与其他各组间差异均有统计学意义（P〈0.05）；在瘤旁1cm区域，高级别胶质瘤组与其他各组间差异均有统计学意义（P〈0.05），低级别胶质瘤组与转移瘤组间差异有统计学意义（P〈0.05）。各组脑肿瘤瘤区实性区域与瘤旁1cm及2cm区域差异均有统计学意义（P〈0.05），其中高级别胶质瘤组及转移瘤组瘤旁1cm与2cm区域间差异有统计学意义（P〈O.05）。Pearson相关分析结果显示同组肿瘤相同区域两指标均显著正相关。结论DSC技术在脑肿瘤术前病理学级别评估及鉴别诊断中具有重要的应用价值。Objective To evaluate the value of dynamic susceptibility contrast-enhanced MR imaging （DSC） in evaluation of brain tumor after operation. Methods 41 cases with brain tumors verified histologically,including 8 cases of high-grade gliomas, 16 of low-grade gliomas, 7 of metastases and 10 of meningiomas underwent DSC examination. All the cases at 3.0T MR unit. All primitive data were sent to ADW4.3 workstation for post-processing. The mean maximal rCBV and rCBF ratios of tumors, 1 cm and 2 cm regions of peri-tumor were obtained respectively. The relativity of MR perfusion parameters（rCBV and rCBF）between diferent tumors were statistically evaluated by using Pearson correlative analysis. Results In the solid region of tumors,rCBV and rCBF were statistically significant differences （P〈0.05）between low-grade gliomas and the other three groups of tumors; in 1 cm region of peri-tumor between high-grade gliomas and the other three groups,and between low-grade gliomas and metastases,between the solid region and both regions of 1 cm and 2 cm peri-tumors at the same tumor were all of statistically significant differences（P〈0.05）, between 1 cm and 2 cm region of peri-tumors at high-grade gliomas and metastases, the rCBV and rCBF were also of statisti-cally significant differences. Pearson correlative analysis showed that there were significant positive correlations between the mean maximal rCBV and rCBF ratios at the same region in the same tumor＇s group. Conclusion DSC is very valuable in evaluation of the histopathological grade and the differentiation of brain tumor.

关 键 词：脑 肿瘤 动态磁敏感对比增强 磁共振灌注成像 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]