成纤维细胞激活蛋白在食管癌中的表达及意义  

Expression of fibroblast activation protein and its clinical significance in esophageal cancer

作　　者：王海云[1] 董卫国[1] 杨子荣[1] 朱红霞[1] 雷晓斐[1] 

机构地区：[1]武汉大学人民医院消化内科,湖北武汉430060

出　　处：《胃肠病学和肝病学杂志》2009年第12期1102-1104,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨成纤维细胞激活蛋白(fibroblast activation protein,FAP)与食管癌进展的关系及其在食管癌早期诊断中的价值。方法应用免疫组化SP方法检测食管癌组织芯片中FAP的表达情况,并结合临床病理参数进行相关分析。结果68例食管癌组织中FAP阳性表达57例,总阳性率达83.8%,而在5例正常食管组织中则无表达。经过分析发现,FAP的阳性表达率与食管癌分化程度相关(P<0.05),随着肿瘤恶性程度的增加,FAP的表达减少,而与性别、年龄以及TNM分期无明显相关(P>0.05)。结论FAP在食管癌组织中的表达与食管癌细胞的分化程度相关,因此可作为反映食管癌恶性生物学行为的一个较有价值的指标。Objective To investigate the significance of fibroblast activation protein （FAP） expression in esophageal cancer as well as its role in early diagnosis. Methods The expression of FAP in esophageal cancer （tissue chip） was examined by immunohistoehemical staining, and the result was analyzed with elinicopathologieal parameters. Results Fifty-seven cases of 68 （83.8%） in esophageal cancer were positive expression of FAP, while normal tissues were negative. Significant correlation was found between FAP expression and the differentiation degree （P 〈 0. 05）. With the malignant degree of the tumor increased, the expression of FAP decreased. Its relation to the gender, age and TNM stage was not significant （P 〉0.05）. Conclusion Significant correlation was found between FAP expression and the tumor differentiation degree, and FAP may be a useful tumor marker for early diagnosis in esophageal cancer.

关 键 词：食管癌 成纤维细胞激活蛋白(FAP) 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]