肺癌骨转移放疗止痛治疗剂量学与临床疗效分析  

Radiotherapy for painful bone metastases of lung cancer:the various dose fractionation schedules and the clinical effect analysis

作　　者：张军[1] 付彬玉[1] 李涛[1] 郎锦义[1] 

机构地区：[1]四川省肿瘤医院放疗科,四川成都610041

出　　处：《四川医学》2009年第12期1883-1884,共2页Sichuan Medical Journal

摘　　要：目的分析肺癌骨转移不同分割方式放疗止痛的剂量学特点和止痛疗效。方法对176例肺癌骨转移患者共247个病灶的放疗止痛疗效进行回顾性分析。放疗方式分为5种剂量分割组：A组：2Gy次/,5次/周,总量40-50Gy;B组：3Gy次/,5次/周,总量30-42Gy;C组：4Gy次/,5次/周,总量32-36Gy;D组：5Gy次/,5次/周,总量30Gy;E组：10Gy次/,1次/周,总量20Gy。结果5个组的止痛有效率分别为89.1%、91.9%、89.3%、89.2%、71.4%,各组的止痛有效率差异无统计学意义,总有效率为89.9%。大分割组（D组和E组）的止痛起效时间明显短于常规分割组（A组）。结论放疗是肺癌骨转移的一种有效止痛方式,疗效确切,不良反应小,患者耐受性好,可作为肺癌骨转移止痛的首选治疗方法。不同分割剂量放疗对骨转移疼痛的止痛疗效无影响。Objective To compare pain relief among various dose fractionation schedules of localized radiotherapy in the treatment of painful bone metastases of lung cancer. Methods 176 patients with painful bone metastases of lung cancer were investigated. There were five radiotherapy group in the study： Group A： 2Gy/f, 5 f/w, Dt 40 - 50Gy; Group B ： 3 Gy/f, 5 f/w, Dt 30 - 42Gy;Group C：4Gy/f,Sf/w,Dt 32 -36Gy;Group D：5Gy/f,Sf/w,Dt 30Gy;Group E：lOGy/f, lf/w,Dt 20Gy. Results Pain relief rates were 89. 1% ,91.9% ,89. 3% ,89. 2% ,71.4% ,respectively in different groups. There was no significant difference in all groups. The overall pain relief rate was 89.9%. Hypofractionated radiotherapy for pain onset time is short. Conclusion Radiotherapy for painful bone metastases of lung cancer is effective, and could be the first choice. However, the study shows no significant difference in pain relief rates between different dose fractionations.

关 键 词：肺癌 骨转移 放射治疗 

分 类 号：R734.2[医药卫生—肿瘤]