术前先期化疗及腔内放疗治疗Ⅰb_2-Ⅱa期宫颈癌临床分析  

Clinical analysis of the effects of neoadjuvant chemotherapy plus preoperative vaginal intracavitary irradiation for stage Ⅰb_2 and Ⅱa cervical cancer

作　　者：张蓓[1] 谢永[1] 李志芳[1] 徐梅[1] 王光慧[1] 

机构地区：[1]徐州市中心医院妇科,江苏徐州221009

出　　处：《徐州医学院学报》2009年第12期872-874,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的探讨Ⅰb2-Ⅱa期宫颈癌术前先期治疗方法,进一步提高手术治疗临床效果。方法68例Ⅰb2-Ⅱa期宫颈癌患者分为3组平行对照,手术治疗前分别应用全身化疗、腔内后装放疗、全身化疗+腔内后装放疗进行先期治疗,手术治疗后比较3种先期治疗方法在肿瘤组织的消退、病理改变、淋巴结转移和宫旁浸润方面的效果。结果先期全身化疗+腔内后装放疗方法在缩小肿瘤体积、减少宫旁浸润、降低淋巴结转移率等方面明显优于先期全身化疗、腔内后装放疗。结论全身化疗+腔内后装放疗方法是Ⅰb2-Ⅱa期宫颈癌术前先期治疗的良好选择。Objective To discuss the value of different ways of preoperative treatments in patients with stage Ⅰb2 and Ⅱa cervical cancer and further improve clinical effect of operative treatment.Methods Data from 68 patients with stageⅠb2 andⅡa cervical cancer were collected in our hospital.The patients were randomly divided into three groups for synchronic treatment.Group A received preoperative intracavitary brachytherapy and chemotherapy.Group B received preoperative chemotherapy alone.Group C only received preoperative intracavitary brachytherapy.The tumor volume shrinkage,postoperative pathological changes,lymph node metastasis and latero-uterus infiltration among the three groups during operation were compared.Results Group A had significant decrease in the tumor volume,latero-uterus infiltration and lymph node metastasis as compared to group B and group C.Conclusion Neoadjuvant chemotherapy plus preoperative vaginal intracavitary irradiation is a better preoperative treatment regimen for stage Ⅰb2 and Ⅱa cervical cancer.

关 键 词：先期治疗 全身化疗 腔内放疗 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]