托拉塞米合成研究  

Study on Synthesis of Torasemid

作　　者：赵世明[1] 尚嘉鹏[1] 李倩[2] 罗振福[1] 

机构地区：[1]天津药物研究院化学制药研究部,天津300193 [2]天津理工大学化学与化工工程学院,天津300384

出　　处：《精细化工中间体》2009年第6期29-30,共2页Fine Chemical Intermediates

摘　　要：以4-羟基吡啶为起始原料,依次经磺化、氯化、酰胺化、取代、缩合反应得到成品。总收率为37.9%,并对合成工艺进行了优化,工艺适合于工业化生产。4-Hydroxypyridine was converted into torasemid in several steps, i.e. sulfonation, chlorination, acylation, substitution and condensation, in an overal yield of 37.9%. The reaction conditions were optimized and apt to be scaled up.

关 键 词：4-羟基吡啶 合成 优化 

分 类 号：TQ253.2[化学工程—有机化工]