酒精戒断致震颤谵妄患者脑电图异常与预后的关系  

Relationship between EEG abnormalities and prognosis of patients with alcohol withdrawal-induced delirium tremens

作　　者：陈景清[1] 张潇[1] 冯俊慧[1] 

机构地区：[1]山东省安康医院,272051

出　　处：《上海精神医学》2009年第6期349-351,共3页Shanghai Archives of Psychiatry

摘　　要：目的分析住院戒酒诱发震颤谵妄患者脑电图(EEG)与预后的关系。方法对住院戒酒治疗的168例慢性酒精中毒患者,根据患者在住院戒酒期间是否发生震颤谵妄分为震颤谵妄组(研究组,36例)和非震颤谵妄组(对照组,132例),检查震颤谵妄发生前后脑电图,并应用酒精戒断综合征评定量表评估戒断症状。结果入院时研究组EEG异常者为86%,对照组为31%,差异有统计学意义(χ2=35.023,P<0.001);震颤谵妄后EEG异常100%,轻度19%、中度56%、重度25%。EEG轻度异常者谵妄症状消失时间中位数为69h、中度异常者为153h、重度异常者为269h,差异有统计学意义(H=24.049,P<0.001)。结论脑电图异常可能提示慢性酒精中毒戒酒诱发震颤谵妄,脑电图异常程度越高,震颤谵妄的预后越差。Objective： To analyze relationship between abnormal EEG and prognosis of hospitalized patients with alcohol withdrawal -induced delirium tremens. Methods： One hundred sixty- eight chronic alcoholism patients treated in hospital were divided per presence of delirium tremens as delirium tremens group （study group, n = 36） and non -delirium group （control group, n = 132）. EEG was measured before and after occurrence of delirium tremens. Withdrawal symptoms were evaluated by alcohol withdrawal syndrome scale. Results：At admission, occurrence rate of abnormal EEG was 86% in study group and 31% in control group. There was significant difference between two groups （χ^2=35. 023,P 〈 0.001 ）. After occurrence of delirium tremens, occurrence rate of abnormal EEG was 100%. Among these, 19% were of mild type, 56% were of moderate type and 25% were of severe type. Median time to remission of delirium was 69 hours in mild type, 153 hours in moderate type and 269 hours in severe type. There was significant difference in time to remission of delirium among three types （H = 24. 049, P 〈 0.001 ）. Conclusion：EEG abnormalities may indicate delirium tremens induced by alcohol withdrawal in chronic alcoholism patients. Severer EEG abnormalities may predict worse prognosis.

关 键 词：慢性酒精中毒 震颤谵妄 脑电图 预后 

分 类 号：R749.6[医药卫生—神经病学与精神病学]