结直肠癌手术后早期肠内营养支持与生长抑素联合应用的临床观察  

Clinical study on application of early enteral nutrition combined with Somatostatin in the after colorectal cancer surgery

作　　者：胡石奇[1] 刘振邦[1] 陈熙文[1] 杨平[1] 唐伟镖[1] 

机构地区：[1]广州市第一人民医院普通外科,510180

出　　处：《中华普通外科学文献（电子版）》2009年第6期43-45,共3页Chinese Archives of General Surgery(Electronic Edition)

基　　金：广东省科技计划项目(2006B30005);广州市医药卫生科技项目(2006-YB-021)

摘　　要：目的探讨结直肠癌手术后早期肠内营养支持(EEN)与生长抑素(SS)联合应用的效果㈦可行性。方法将80例已确诊结直肠癌接受手术治疗的住院患者依照随机数余数分组法随机分为试验组与对照组,每组40例,术后6h起均给予相同方式的EEN措施,试验组同时加用SS,连续观察5～7d;比较两组术后肠蠕动恢复㈦肛门排气时间,术后2d腹痛腹胀发生率、胃肠减压量及术后3d、7d的血常规和肝、肾功能及血糖、电解质等指标。结果与对照组比较,试验组的腹痛腹胀发生率(P<0.05)及胃肠减压量(P<0.01)差异有统计学意义;术后肠蠕动恢复与肛门排气时间,以及3d、7d血常规和肝、肾功能及血糖、电解质等指标的比较差异无统计学意义。结论结直肠癌手术后早期肠内营养支持与生长抑素联合应⒚安全、合理,切实可行。Objective To investigate the therapeutic effect, safety and the resumption of gastrointestinal function of early enteral nutrition （EEN） combined with Somatostatin （SS） in the patients after colorectal cancer surgery. Methods 80 patients who accepted colorectal cancer surgery were selected and randomly divided into two groups, including 40 cases of treatment group with SS on the basis of EEN and 40 cases of control group with EEN, Some aspects were analyzed between the two groups before and after the operations, which includes the times of recovering peristalsis and passing flatus, promoted clinical manifestation and signs, gastrointestinal decompression, blood routine examinations, liver and renal function, blood glucose, electrolytes and so on. Results As for clinical manifestation and sign promotion, there was statistically significance in the alleviation of pain and disten- sion of the abdominal （P 〈0.05） and the average volume of gastrointestinal decompression （P〈0.01） between the treatment group and the control group after 2 d of surgery. It indicated the treatment group was better than the control group in therapeutic results. As for times of recovering peristalsis and passing flatus, blood routine examinations, liver and renal function, blood glucose, electrolytes, there were no statistically significance between the treatment group and the control group. It indicated the therapeutic effect of SS dose not depress the effect of EEN. Conclusions EEN combined with SS is a safe and effective peri-operation treatment, can obviously promote clinical symptom, and increase the achievement ratio of expectant treatment.

关 键 词：结直肠癌 外科手术 肠道营养 生长抑素 

分 类 号：R735.3[医药卫生—肿瘤]