抑郁症与焦虑症脑血流灌注SPECT显像对照研究  

Comparative study of SPECT between patients with depressive disorder and anxiety disorders

作　　者：金玉新[1] 高德九[1] 刘琳[1] 

机构地区：[1]甘肃省白银市第一人民医院核医学科,甘肃白银730900

出　　处：《中国临床医学影像杂志》2009年第12期885-888,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:探讨抑郁症、焦虑症患者局部脑血流量(rCBF)的特点及脑单光子计算机断层扫描(SPECT)对抑郁症的诊断价值。方法:对21例抑郁症患者、17例焦虑症患者和20例正常对照者进行脑SPECT显像,并比较检查结果。结果:抑郁症组与正常对照组比较,双侧前额叶、颞叶前部、双侧扣带回前部、双侧顶叶、枕叶以及尾状核rCBF明显低于正常对照组(P<0.05或0.01)。焦虑症组与正常对照组比较,额叶、部分颞叶和丘脑的rCBF明显低于正常对照组(P<0.05或0.01)。抑郁症组与焦虑症组相比较,抑郁症组在双侧扣带回前部、右顶叶及尾状核的rCBF明显低于焦虑症组(P<0.05或0.01)。结论:抑郁症和焦虑症对脑血流灌注均有重要影响,抑郁症患者在双侧扣带回前部、右顶叶及尾状核的脑血流灌注明显低于焦虑症组。SPECT脑灌注显像在抑郁症和焦虑症的诊断与鉴别诊断中具有重要价值。Objective： To study the characteristics of regional cerebral blood flow （rCBF） and the diagnostic value of brain SPECT in patients with depressive disorder and anxiety disorders. Methods： SPECT were performed in 21 depressive patients, 17 anxiety patients to compare the difference in cerebral perfusion. Region of interest （ROI） in cross-sectional images of the brain lobes were drawn, to semi-quantitatively analyse the rCBF changes of depression and anxiety disorders in patients. The t test was used to analyze the quantitative data. Results： Lower radioactivity rate in bilateral prefrontal lobes, temporal lobes, occipital lobes, bilateral parietal lobes, cingulated gyrus, caudate nucleus were demonstrated in the depressive patients （P〈0.05 or 0.01）. Lower radioactivity rate in bilateral frontal lobes, anterior temporal lobes and cerebral ganglion were demonstrated in the anxiety patients （P〈0.05 or 0.01）. Conclusion： The depressive disorder and anxiety disorders have obvious effect on cerebral blood flow. Radionuelide imaging have important value in the diagnosis and differential diagnosis of depressive disorder and anxiety disorders.

关 键 词：抑郁症 焦虑症 体层摄影术 发射型计算机 单光子 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R749.72[医药卫生—临床医学]