S/D处理结合低pH放孵灭活静注人免疫球蛋白  

Both lnactivations of S/D Treatment and Low pH lncubation for Hman lmmunoglobulin products

作　　者：李振平[1] 程夷[1] 张艳荣[1] 吕新华[1] 张安山[1] 

机构地区：[1]卫生部兰州生物制品研究所

出　　处：《微生物学免疫学进展》1998年第3期27-29,共3页Progress In Microbiology and Immunology

摘　　要：在低ｐＨ静脉注射用人免疫球蛋白（ＩＶＩＧ）的制备中，采用有机溶剂／表面活性剂处理和低ｐＨ放孵（２３°Ｃ～２５°Ｃ，２１天）进行病毒灭活，以提高ＩＶＩＧ的安全性，两法累积灭活效果为：＞８ｌｏｇＨＩＶ－Ⅰ；＞１１．３ＬｏｇＶＳＶ和＞１０．８ＬｏｇＳｉｎｄｂｉｓ。Both solvent/detergent treatment and low pH incubation were used in the preparation of low pH intravenous immunoglobulin with cold alcohol fractionation to improve the products safety.The results showed that accumulated amount of inactivation of viruses by above two steps was >8 log HIVⅠ;>11.3 log VSV and >10.8 Log Sindbis.

关 键 词：静注丙球 免疫球蛋白 病毒灭活 S/D处理 

分 类 号：R977.6[医药卫生—药品] R392－33[医药卫生—药学]