神经胶质细胞在IBS内脏高敏感性中作用的展望  

Advance on the study of the Role of Glial Cells in Visceral hyperalgesia of IBS

作　　者：崔曼莉[1] 王景杰[1] 黄裕新[1] 

机构地区：[1]第四军医大学唐都医院消化内科,陕西西安710038

出　　处：《现代生物医学进展》2009年第21期4155-4157,共3页Progress in Modern Biomedicine

摘　　要：肠易激综合征(IBS)是一种慢性功能性肠道疾病,其发病率呈上升趋势,其发病主要特点是内脏高敏感性增高,但其神经生物学机制尚不完全清楚,因此对其发病机制研究有较重要意义。研究表明,神经胶质细胞在内脏痛反应中可能起较为重要作用,尤其是脊髓中支配左半结肠的骶髓后连合核团中神经胶质细胞与IBS内脏高敏感性可能具有密切相关性。本文拟于对神经胶质细胞在IBS内脏高敏感性中作用的研究进展作一综述。Irritable bowel syndrome is a chronic intestinal function disease and the morbidity increases. .Visceral hypersensitivity is one of the pathogenesis.But the neuronal mechanism is unkown. Investigating the neuronal mechanisms may represent a valuable therapeutic target for IBS management and develop the IBS patients life quality to some extent. Accumulating evidence over last several years indicates an important role of glial cells in the visceral hypersensitivity of IBS. This paper reviewed the lastest Investigate on Progress on the Role of Glial Cells in Visceral hyperalgesia of IBS.

关 键 词：肠易激综合征 内脏高敏感性 骶髓后连合核 神经胶质细胞 

分 类 号：R574[医药卫生—消化系统] R338[医药卫生—内科学]