原发性肝癌患者血清和血浆中VEGF检测的临床意义  

Comparison between Serum and Plasma Vascular Endothelial Growth Factor in Hepatocellular Carcinoma and its Clinical Significance

作　　者：杨贵义[1] 

机构地区：[1]随州市中心医院普外科,湖北随州441300

出　　处：《医学新知》2009年第6期331-333,337,共4页New Medicine

摘　　要：目的检测原发性肝癌（HCC）患者血清和血浆血管内皮生长因子（VEGF），探讨其临床意义。方法38例HCC、20例肝良性病变（10例肝血管瘤，10例慢性肝炎肝硬化）和10例正常对照者。分别用ELISA法和免疫组织化学方法检测外周血（血清和血浆）VEGF的表达水平，比较各组间外周血VEGF浓度的差异并分析外周血VEGF与HCC临床病理特征的关系。结果HCC患者血浆和血清VEGF均与HCC临床病理特征相关，其总体水平高于良性肝病组和正常对照组（P〈0．05）；但在Ia期HCC，血清VEGF浓度与正常对照组间没有显著性差异（P〉0．05），而血浆VEGF高于对照组（P〈0．05）。结论血管生成和HCC生物学行为有关，血清和血浆VEGF均反映了HCC生物学状态，血浆VEGF可能更为敏感。Objective To explore the significance of serum and plasma vascular endothelial growth factor （VEGF） in hepatocellular carcinoma （HCC）. Methods Peripheral VEGF of 38 HCC patients, 10 cases of hepatic haemangioma, 10 of liver cirrhosis, and 10 normal control was tested by enzyme - linked immunoadsordent assay, and VEGF was also immunohistochemically examined. Correlation be- tween the expression of VEGF and clini -pathotical character was analyzed, and difference between serum and plasma VEGF was also compared. Results VEGF in peripheral blood and tumor tissue was both correlated to the clini - pathotic features of HCC, serum and plasma VEGF were both statically higher than in rest groups. In Ia phase group, plasma VEGF was statically higher than that in control group, but such a difference in serum VEGF was not observed. Conclusion Angiogenesis is correlated to biological behavior of HCC. Serum and plasma VEGF are both essential markers to evaluate the biologic state of HCC, the latter being more sensitive.

关 键 词：肝细胞癌 血管内皮生长因子 血管生成 

分 类 号：R735.7[医药卫生—肿瘤]